Assessment of the dielectric properties of drug sensitive and resistant leukaemic cells before and after ion channel blockers using dielectroplioresis

L. Duncan, H. Shelmerdine, H. M. Coley, F. H. Labeed

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Citations (Scopus)

Abstract

Dielectrophoresis (DEP) is a phenomenon of induced particle motion in non-uniform electric fields. The effect is frequency dependent; by monitoring the motion of particles in AC fields and analysing the change in motion with frequency, it is possible to determine the electrical properties of single cells in lab-on-a-chip systems. In this paper we use DEP to study the electrical properties of drug-sensitive and drug-resistant cancer cells before and after treatment with ion channel blocking agents, which give insight into the origin of cytoplasmic differences shown to have a significant bearing on the origin of drug resistance in cancer.

Original languageEnglish
Title of host publication2006 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2006 Technical Proceedings
Pages45-48
Number of pages4
Publication statusPublished - 2006
Externally publishedYes
Event2006 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2006 Technical Proceedings - Boston, MA, United States
Duration: May 7 2006May 11 2006

Publication series

Name2006 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2006 Technical Proceedings
Volume2

Other

Other2006 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2006 Technical Proceedings
Country/TerritoryUnited States
CityBoston, MA
Period5/7/065/11/06

Keywords

  • Blockers
  • Conductivity
  • Dielectrophoresis
  • Ion channel

ASJC Scopus subject areas

  • General Engineering

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