Assessment of the dielectric properties of drug sensitive and resistant leukaemic cells before and after ion channel blockers using dielectroplioresis

L. Duncan; H. Shelmerdine; H. M. Coley; F. H. Labeed

Assessment of the dielectric properties of drug sensitive and resistant leukaemic cells before and after ion channel blockers using dielectroplioresis

L. Duncan
, H. Shelmerdine
, H. M. Coley
, F. H. Labeed

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

Dielectrophoresis (DEP) is a phenomenon of induced particle motion in non-uniform electric fields. The effect is frequency dependent; by monitoring the motion of particles in AC fields and analysing the change in motion with frequency, it is possible to determine the electrical properties of single cells in lab-on-a-chip systems. In this paper we use DEP to study the electrical properties of drug-sensitive and drug-resistant cancer cells before and after treatment with ion channel blocking agents, which give insight into the origin of cytoplasmic differences shown to have a significant bearing on the origin of drug resistance in cancer.

Original language	English
Title of host publication	2006 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2006 Technical Proceedings
Pages	45-48
Number of pages	4
Publication status	Published - 2006
Externally published	Yes
Event	2006 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2006 Technical Proceedings - Boston, MA, United States Duration: May 7 2006 → May 11 2006

Publication series

Name	2006 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2006 Technical Proceedings
Volume	2

Other

Other	2006 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2006 Technical Proceedings
Country/Territory	United States
City	Boston, MA
Period	5/7/06 → 5/11/06

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Blockers
Conductivity
Dielectrophoresis
Ion channel

ASJC Scopus subject areas

General Engineering

Cite this

Duncan, L., Shelmerdine, H., Coley, H. M., & Labeed, F. H. (2006). Assessment of the dielectric properties of drug sensitive and resistant leukaemic cells before and after ion channel blockers using dielectroplioresis. In 2006 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2006 Technical Proceedings (pp. 45-48). (2006 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2006 Technical Proceedings; Vol. 2).

Assessment of the dielectric properties of drug sensitive and resistant leukaemic cells before and after ion channel blockers using dielectroplioresis. / Duncan, L.; Shelmerdine, H.; Coley, H. M. et al.
2006 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2006 Technical Proceedings. 2006. p. 45-48 (2006 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2006 Technical Proceedings; Vol. 2).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Duncan, L, Shelmerdine, H, Coley, HM & Labeed, FH 2006, Assessment of the dielectric properties of drug sensitive and resistant leukaemic cells before and after ion channel blockers using dielectroplioresis. in 2006 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2006 Technical Proceedings. 2006 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2006 Technical Proceedings, vol. 2, pp. 45-48, 2006 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2006 Technical Proceedings, Boston, MA, United States, 5/7/06.

Duncan L, Shelmerdine H, Coley HM, Labeed FH. Assessment of the dielectric properties of drug sensitive and resistant leukaemic cells before and after ion channel blockers using dielectroplioresis. In 2006 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2006 Technical Proceedings. 2006. p. 45-48. (2006 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2006 Technical Proceedings).

Duncan, L. ; Shelmerdine, H. ; Coley, H. M. et al. / Assessment of the dielectric properties of drug sensitive and resistant leukaemic cells before and after ion channel blockers using dielectroplioresis. 2006 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2006 Technical Proceedings. 2006. pp. 45-48 (2006 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2006 Technical Proceedings).

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title = "Assessment of the dielectric properties of drug sensitive and resistant leukaemic cells before and after ion channel blockers using dielectroplioresis",

abstract = "Dielectrophoresis (DEP) is a phenomenon of induced particle motion in non-uniform electric fields. The effect is frequency dependent; by monitoring the motion of particles in AC fields and analysing the change in motion with frequency, it is possible to determine the electrical properties of single cells in lab-on-a-chip systems. In this paper we use DEP to study the electrical properties of drug-sensitive and drug-resistant cancer cells before and after treatment with ion channel blocking agents, which give insight into the origin of cytoplasmic differences shown to have a significant bearing on the origin of drug resistance in cancer.",

keywords = "Blockers, Conductivity, Dielectrophoresis, Ion channel",

author = "L. Duncan and H. Shelmerdine and Coley, \{H. M.\} and Labeed, \{F. H.\}",

year = "2006",

language = "English",

isbn = "0976798573",

series = "2006 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2006 Technical Proceedings",

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AU - Duncan, L.

AU - Shelmerdine, H.

AU - Coley, H. M.

AU - Labeed, F. H.

PY - 2006

Y1 - 2006

N2 - Dielectrophoresis (DEP) is a phenomenon of induced particle motion in non-uniform electric fields. The effect is frequency dependent; by monitoring the motion of particles in AC fields and analysing the change in motion with frequency, it is possible to determine the electrical properties of single cells in lab-on-a-chip systems. In this paper we use DEP to study the electrical properties of drug-sensitive and drug-resistant cancer cells before and after treatment with ion channel blocking agents, which give insight into the origin of cytoplasmic differences shown to have a significant bearing on the origin of drug resistance in cancer.

AB - Dielectrophoresis (DEP) is a phenomenon of induced particle motion in non-uniform electric fields. The effect is frequency dependent; by monitoring the motion of particles in AC fields and analysing the change in motion with frequency, it is possible to determine the electrical properties of single cells in lab-on-a-chip systems. In this paper we use DEP to study the electrical properties of drug-sensitive and drug-resistant cancer cells before and after treatment with ion channel blocking agents, which give insight into the origin of cytoplasmic differences shown to have a significant bearing on the origin of drug resistance in cancer.

KW - Blockers

KW - Conductivity

KW - Dielectrophoresis

KW - Ion channel

UR - https://www.scopus.com/pages/publications/33845192979

UR - https://www.scopus.com/pages/publications/33845192979#tab=citedBy

M3 - Conference contribution

AN - SCOPUS:33845192979

SN - 0976798573

SN - 9780976798576

T3 - 2006 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2006 Technical Proceedings

SP - 45

EP - 48

BT - 2006 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2006 Technical Proceedings

T2 - 2006 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2006 Technical Proceedings

Y2 - 7 May 2006 through 11 May 2006

ER -

Assessment of the dielectric properties of drug sensitive and resistant leukaemic cells before and after ion channel blockers using dielectroplioresis

Abstract

Publication series

Other

UN SDGs

Keywords

ASJC Scopus subject areas

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