Assignment of the porcine calcium release channel gene, a candidate for the malignant hyperthermia locus, to the 6p11 → q21 segment of chromosome 6

Ingrid Harbitz, Bhanu Chowdhary, Preben D. Thomsen, William Davies, Uwe Kaufmann, Sissel Kran, Ingemar Gustavsson, Knud Christensen, Jens G. Hauge

Research output: Contribution to journalArticlepeer-review

87 Citations (Scopus)

Abstract

Several studies point to the possibility that malignant hyperthermia (MH) in pigs is caused by a defect in the calcium release channel (CRC) of skeletal muscle sarcoplasmic reticulum. The locus for MH is closely linked to the glucosephosphate isomerase (GPI) locus, near the centromere of chromosome 6. We demonstrate synteny of the genes for CRC and GPI using somatic cell hybrid lines, and assign the CRC gene to chromosome 6p11 → q21 by in situ hybridization.

Original languageEnglish
Pages (from-to)243-248
Number of pages6
JournalGenomics
Volume8
Issue number2
DOIs
Publication statusPublished - Oct 1990
Externally publishedYes

ASJC Scopus subject areas

  • Genetics

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