Associating community prevalence of Schistosoma mansoni infection with prevalence of signs and symptoms

Marieke J. Van Der Werf, Sake J. De Vlas, Caspar W.N. Looman, Nico J.D. Nagelkerke, J. Dik F. Habbema, Dirk Engels

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)


Information on the prevalence of morbidity is needed for re-calculation of the Global Burden of Disease (WHO) due to Schistosoma mansoni. This study presents a statistical association which can be used to predict the prevalence of morbidity from the prevalence of S. mansoni in a community. We collected data from field studies reporting prevalence of infection and prevalence of morbidity. Data on infection prevalence were standardised to a default diagnostic sensitivity (i.e. Kato-Katz technique 41.7 mg). The data were described by an expression related to logistic regression. We determined associations between prevalence of infection and prevalence of early morbidity (diarrhoea, blood in stool and abdominal pain), hepatosplenic morbidity and late morbidity (haematemesis and ascitis). Diarrhoea and blood in stool due to S. mansoni infection mainly occurs in communities with a high prevalence of infection. An influence on hepatosplenic morbidity is already present at low community prevalence of infection. For the aspecific symptom abdominal pain we did not find an association.

Original languageEnglish
Pages (from-to)127-137
Number of pages11
JournalActa Tropica
Issue number2
Publication statusPublished - 2002
Externally publishedYes


  • Abdominal pain
  • Ascitis
  • Blood in stool
  • Diarrhoea
  • Haematemesis
  • Hepatomegaly
  • Morbidity
  • Pathology
  • Schistosoma mansoni
  • Schistosomiasis
  • Splenomegaly

ASJC Scopus subject areas

  • Parasitology
  • veterinary (miscalleneous)
  • Insect Science
  • Infectious Diseases


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