TY - JOUR
T1 - Association between HCV infection and diabetes type 2 in Egypt
T2 - Is it time to split up?
AU - Cuadros, Diego F.
AU - Miller, F. De Wolfe
AU - Nagelkerke, Nico
AU - Abu-Raddad, Laith J.
N1 - Funding Information:
This study was made possible by JSREP grant number 3-014-3-007 from the Qatar National Research Fund (a member of Qatar Foundation). Additional support was provided by the Biostatistics, Epidemiology, and Biomathematics Research Core at the Weill Cornell Medical College in Qatar. The authors are also thankful for Measure Demographic and Health Surveys (measure DHS) for putting these data in the service of science, and for the U.S. Agency for International Development and other donors supporting these initiatives. The statements made herein are solely the responsibility of the authors, and the funders had no role in the design, conduct, or analysis of the study.
Publisher Copyright:
© 2015 The Authors.
PY - 2015/12/1
Y1 - 2015/12/1
N2 - Purpose: There is a conflicting evidence about the association between hepatitis C virus (HCV) infection and diabetes mellitus. The objective of this study was to assess this association in Egypt, the country with the highest HCV prevalence in the world. Methods: The source of data was from the Egypt Demographic and Health Survey conducted in 2008. Using multivariable logistic regression analyses to account for known confounders, the association was investigated at two levels']: (1) HCV exposure (HCV antibody status) and diabetes mellitus and (2) diabetes mellitus and chronic HCV infection (HCV RNA status) among HCV-exposed individuals. Results: We found no evidence for an association between HCV antibody status and diabetes (adjusted odds ratio [OR] = 0.87; 95% confidence interval [CI], 0.63-1.19). However, among HCV-exposed individuals, we found an evidence for an association between diabetes and active HCV infection (adjusted OR = 2.44, 95% CI, 1.30-4.57). Conclusions: Although it does not appear that HCV exposure and diabetes are linked, there might be an association between diabetes and chronic HCV infection. The HCV-diabetes relationship may be more complex than previously anticipated. Therefore, a call for an "amicable divorce" to the HCV-diabetes relationship could be premature.
AB - Purpose: There is a conflicting evidence about the association between hepatitis C virus (HCV) infection and diabetes mellitus. The objective of this study was to assess this association in Egypt, the country with the highest HCV prevalence in the world. Methods: The source of data was from the Egypt Demographic and Health Survey conducted in 2008. Using multivariable logistic regression analyses to account for known confounders, the association was investigated at two levels']: (1) HCV exposure (HCV antibody status) and diabetes mellitus and (2) diabetes mellitus and chronic HCV infection (HCV RNA status) among HCV-exposed individuals. Results: We found no evidence for an association between HCV antibody status and diabetes (adjusted odds ratio [OR] = 0.87; 95% confidence interval [CI], 0.63-1.19). However, among HCV-exposed individuals, we found an evidence for an association between diabetes and active HCV infection (adjusted OR = 2.44, 95% CI, 1.30-4.57). Conclusions: Although it does not appear that HCV exposure and diabetes are linked, there might be an association between diabetes and chronic HCV infection. The HCV-diabetes relationship may be more complex than previously anticipated. Therefore, a call for an "amicable divorce" to the HCV-diabetes relationship could be premature.
KW - Chronic infection
KW - Diabetes
KW - Egypt
KW - Hepatitis C virus
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U2 - 10.1016/j.annepidem.2015.09.005
DO - 10.1016/j.annepidem.2015.09.005
M3 - Article
C2 - 26499381
AN - SCOPUS:84952639901
SN - 1047-2797
VL - 25
SP - 918
EP - 923
JO - Annals of Epidemiology
JF - Annals of Epidemiology
IS - 12
ER -