Association of human herpesvirus 6 subtypes with symptomatic apical periodontitis

Katinka Hernádi, Eszter Csoma, Balázs Dám, Anita Szalmás, Eszter Gyöngyösi, György Veress, Ildikó-Márton, József Kónya

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)


Objective: The occurrence of human herpesvirus (HHV) 6 subtypes A and B in apical periodontitis was determined. The relationship of HHV-6 subtypes to other disease associated herpesviruses, i.e., Epstein-Barr virus (EBV) and human cytomegalovirus, was also investigated. Study design: Forty apical periodontitis samples (17 symptomatic and 23 asymptomatic) and 40 healthy pulp control samples were collected. Nested polymerase chain reaction was used to detect HHV-6 DNA. Results: HHV-6 DNA was observed in significantly higher frequencies in apical periodontitis samples than in control samples (20% vs. 2.5%; P =.03). Further classification of apical lesions revealed that subtype B of HHV-6 was significantly associated with large-sized and symptomatic lesions (P <.01). Thirty-one apical lesions (77%) harbored <1 of the tested herpesviruses: EBV was the most frequent herpesvirus (72.5%) in apical periodontitis, followed by HHV-6 (20%). Conclusion: Our findings suggest that EBV and HHV-6B infections can be associated with symptomatic apical periodontitis.

Original languageEnglish
Pages (from-to)401-406
Number of pages6
JournalOral Surgery Oral Medicine and Oral Pathology
Issue number3
Publication statusPublished - Sept 2011
Externally publishedYes

ASJC Scopus subject areas

  • Surgery
  • Oral Surgery
  • Otorhinolaryngology
  • General Dentistry


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