TY - JOUR
T1 - Association of human herpesvirus 6 subtypes with symptomatic apical periodontitis
AU - Hernádi, Katinka
AU - Csoma, Eszter
AU - Dám, Balázs
AU - Szalmás, Anita
AU - Gyöngyösi, Eszter
AU - Veress, György
AU - Ildikó-Márton,
AU - Kónya, József
PY - 2011/9
Y1 - 2011/9
N2 - Objective: The occurrence of human herpesvirus (HHV) 6 subtypes A and B in apical periodontitis was determined. The relationship of HHV-6 subtypes to other disease associated herpesviruses, i.e., Epstein-Barr virus (EBV) and human cytomegalovirus, was also investigated. Study design: Forty apical periodontitis samples (17 symptomatic and 23 asymptomatic) and 40 healthy pulp control samples were collected. Nested polymerase chain reaction was used to detect HHV-6 DNA. Results: HHV-6 DNA was observed in significantly higher frequencies in apical periodontitis samples than in control samples (20% vs. 2.5%; P =.03). Further classification of apical lesions revealed that subtype B of HHV-6 was significantly associated with large-sized and symptomatic lesions (P <.01). Thirty-one apical lesions (77%) harbored <1 of the tested herpesviruses: EBV was the most frequent herpesvirus (72.5%) in apical periodontitis, followed by HHV-6 (20%). Conclusion: Our findings suggest that EBV and HHV-6B infections can be associated with symptomatic apical periodontitis.
AB - Objective: The occurrence of human herpesvirus (HHV) 6 subtypes A and B in apical periodontitis was determined. The relationship of HHV-6 subtypes to other disease associated herpesviruses, i.e., Epstein-Barr virus (EBV) and human cytomegalovirus, was also investigated. Study design: Forty apical periodontitis samples (17 symptomatic and 23 asymptomatic) and 40 healthy pulp control samples were collected. Nested polymerase chain reaction was used to detect HHV-6 DNA. Results: HHV-6 DNA was observed in significantly higher frequencies in apical periodontitis samples than in control samples (20% vs. 2.5%; P =.03). Further classification of apical lesions revealed that subtype B of HHV-6 was significantly associated with large-sized and symptomatic lesions (P <.01). Thirty-one apical lesions (77%) harbored <1 of the tested herpesviruses: EBV was the most frequent herpesvirus (72.5%) in apical periodontitis, followed by HHV-6 (20%). Conclusion: Our findings suggest that EBV and HHV-6B infections can be associated with symptomatic apical periodontitis.
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U2 - 10.1016/j.tripleo.2011.02.007
DO - 10.1016/j.tripleo.2011.02.007
M3 - Article
C2 - 21546281
AN - SCOPUS:80051548191
SN - 1079-2104
VL - 112
SP - 401
EP - 406
JO - Oral Surgery Oral Medicine and Oral Pathology
JF - Oral Surgery Oral Medicine and Oral Pathology
IS - 3
ER -
