TY - JOUR
T1 - Autophagy and EMT in cancer and metastasis
T2 - Who controls whom?
AU - Gundamaraju, Rohit
AU - Lu, Wenying
AU - Paul, Manash K.
AU - Jha, Niraj Kumar
AU - Gupta, Piyush Kumar
AU - Ojha, Shreesh
AU - Chattopadhyay, Indranil
AU - Rao, Pasupuleti Visweswara
AU - Ghavami, Saeid
N1 - Publisher Copyright:
© 2022 Elsevier B.V.
PY - 2022/9/1
Y1 - 2022/9/1
N2 - Metastasis consists of hallmark events, including Epithelial-Mesenchymal Transition (EMT), angiogenesis, initiation of inflammatory tumor microenvironment, and malfunctions in apoptosis. Autophagy is known to play a pivotal role in the metastatic process. Autophagy has pulled researchers towards it in recent times because of its dual role in the maintenance of cancer cells. Evidence states that cells undergoing EMT need autophagy in order to survive during migration and dissemination. Additionally, it orchestrates EMT markers in certain cancers. On the other side of the coin, autophagy plays an oncosuppressive role in impeding early metastasis. This review aims to project the interrelationship between autophagy and EMT. Targeting EMT via autophagy as a useful strategy is discussed in this review. Furthermore, for the first time, we have covered the possible reciprocating roles of EMT and autophagy and its consequences in cancer metastasis.
AB - Metastasis consists of hallmark events, including Epithelial-Mesenchymal Transition (EMT), angiogenesis, initiation of inflammatory tumor microenvironment, and malfunctions in apoptosis. Autophagy is known to play a pivotal role in the metastatic process. Autophagy has pulled researchers towards it in recent times because of its dual role in the maintenance of cancer cells. Evidence states that cells undergoing EMT need autophagy in order to survive during migration and dissemination. Additionally, it orchestrates EMT markers in certain cancers. On the other side of the coin, autophagy plays an oncosuppressive role in impeding early metastasis. This review aims to project the interrelationship between autophagy and EMT. Targeting EMT via autophagy as a useful strategy is discussed in this review. Furthermore, for the first time, we have covered the possible reciprocating roles of EMT and autophagy and its consequences in cancer metastasis.
KW - Autophagy
KW - Epithelial-Mesenchymal Transition (EMT)
KW - Metastasis
KW - Starvation
KW - Tumor signalling pathways
UR - http://www.scopus.com/inward/record.url?scp=85130417070&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85130417070&partnerID=8YFLogxK
U2 - 10.1016/j.bbadis.2022.166431
DO - 10.1016/j.bbadis.2022.166431
M3 - Article
C2 - 35533903
AN - SCOPUS:85130417070
SN - 0925-4439
VL - 1868
JO - Biochimica et Biophysica Acta - Molecular Basis of Disease
JF - Biochimica et Biophysica Acta - Molecular Basis of Disease
IS - 9
M1 - 166431
ER -