Beneficial Effects of Citrus Flavonoids Against Aβ Pathology in Alzheimer’s Disease

Hayate Javed, Shreesh Kumar Ojha, Mohammad Chand Jamali

Research output: Chapter in Book/Report/Conference proceedingChapter


Amyloid β (Aβ) protein is the major component of extracellular amyloid plaques which are the main pathological feature of Alzheimer’s disease (AD). Disruption in the clearance of Aβ is associated with its accumulation and aggregation that eventually leads to amyloid plaques formation. Numerous drugs have shown to possess therapeutic potential in the treatment of AD, but indeed these drugs only delay the progression of the disease and display numerous side effects. Recently, phytochemicals have drawn much attention in the treatment of neurodegenerative disorders. Among the various phytochemicals, dietary citrus flavonoids have shown potential useful effects against neurological disorders including AD. Dietary citrus flavonoids exhibit a high amount of minerals, vitamins, and antioxidant contents. The present chapter aims to explore the mechanism of Aβ peptide generation, aggregation, and accumulation as well as their prevention through dietary citrus flavonoids.

Original languageEnglish
Title of host publicationCurrent Thoughts on Dementia
Subtitle of host publicationFrom Risk Factors to Therapeutic Interventions
PublisherSpringer Nature
Number of pages18
ISBN (Electronic)9789811676062
ISBN (Print)9789811676055
Publication statusPublished - Jan 1 2022


  • APP
  • Alzheimer’s disease
  • Amyloid β
  • Dementia
  • Flavanone
  • Flavonoids
  • Flavonols
  • Phytochemicals

ASJC Scopus subject areas

  • General Medicine
  • General Neuroscience


Dive into the research topics of 'Beneficial Effects of Citrus Flavonoids Against Aβ Pathology in Alzheimer’s Disease'. Together they form a unique fingerprint.

Cite this