Beneficial Effects of Citrus Flavonoids Against Aβ Pathology in Alzheimer’s Disease

Amyloid β (Aβ) protein is the major component of extracellular amyloid plaques which are the main pathological feature of Alzheimer’s disease (AD). Disruption in the clearance of Aβ is associated with its accumulation and aggregation that eventually leads to amyloid plaques formation. Numerous drugs have shown to possess therapeutic potential in the treatment of AD, but indeed these drugs only delay the progression of the disease and display numerous side effects. Recently, phytochemicals have drawn much attention in the treatment of neurodegenerative disorders. Among the various phytochemicals, dietary citrus flavonoids have shown potential useful effects against neurological disorders including AD. Dietary citrus flavonoids exhibit a high amount of minerals, vitamins, and antioxidant contents. The present chapter aims to explore the mechanism of Aβ peptide generation, aggregation, and accumulation as well as their prevention through dietary citrus flavonoids.