@article{5c7e3a464fee450d9e592a4e52ffc6d5,
title = "Bioactive Fluorenes. Part II. Unprecedented biologically active thiazole derivatives based-2,7-dichlorofluorene as competent DHFR inhibitors: Design, synthesis, and molecular docking approaches",
abstract = "In this study, a new series of (4-(2,7-dichloro-9H-fluoren-4-yl)thiazol-yl)acetamide derivatives was synthesized, and the new heterocycles were completely characterized, evaluated for their antimicrobial activity, and screened for cytotoxic activity against human lung carcinoma (A-549) and human breast carcinoma (MCF-7) cell lines. A molecular docking study was undertaken to identify the possible mode of action of the synthesized compounds, which suggested binding interactions with the dihydrofolate reductase (DHFR) active sites. Most of the synthesized compounds displayed meaningful activity against A-549 and MCF-7 cell lines when compared to 5-fluorouracil (5-FU), which was used as a reference drug. Furthermore, some of the prepared compounds exhibited potent antibacterial and antifungal activities. The highly pronounced biological activities of the compounds under investigation offer such species as promising future drug prospects which may find applications in the fields of biological and medicinal sciences.",
keywords = "Anti-cancer, Antimicrobial, DHFR inhibitors, Fluorene, Molecular docking, Thiazole",
author = "Alsantali, {Reem I.} and Hussein, {Essam M.} and Obaid, {Rami J.} and Moataz Morad and Altass, {Hatem M.} and Ahmed Alharbi and Hameed, {Ahmed M.} and Jassas, {Rabab S.} and Abourehab, {Mohamed A.S.} and Asghar, {Basim H.} and Ziad Moussa and Ahmed, {Saleh A.}",
note = "Funding Information: The authors are highly indebted to the Deanship of the Scientific Research ( DSR ), Umm Al-Qura University , Saudi Arabia for the financial support of this work through project number 18-SCI-1-01-0009 . S. A. Ahmed is highly indebted to Alexander von Humboldt Foundation (AvH) and Prof. Dr. Karola R{\"u}ck-Braun, Technical University Berlin (TU-Berlin), Germany for their endless help and support. Funding Information: The authors are highly indebted to the Deanship of the Scientific Research (DSR), Umm Al-Qura University, Saudi Arabia for the financial support of this work through project number 18-SCI-1-01-0009. S. A. Ahmed is highly indebted to Alexander von Humboldt Foundation (AvH) and Prof. Dr. Karola R?ck-Braun, Technical University Berlin (TU-Berlin), Germany for their endless help and support. Publisher Copyright: {\textcopyright} 2020 The Author(s)",
year = "2020",
month = may,
doi = "10.1016/j.arabjc.2020.03.024",
language = "English",
volume = "13",
pages = "5451--5462",
journal = "Arabian Journal of Chemistry",
issn = "1878-5352",
publisher = "King Saud University",
number = "5",
}