Bioactive properties and untargeted metabolomics analysis of bioaccessible fractions of non-fermented and fermented date fruit pomace by novel yeast isolates

Mutamed Ayyash, Mohammed Tarique, Maitha Alaryani, Ashraf Al-Sbiei, Razan Masad, Besan Al-Saafeen, Maria Fernandez-Cabezudo, Basel al-Ramadi, Jaleel Kizhakkayil, Afaf Kamal-Eldin

Research output: Contribution to journalArticlepeer-review

Abstract

In this study, attempts were made to utilize date by-product (date fruit pomace; DFP). This study aimed to investigate the health-promoting benefits of the fermented and non-fermented DFP before in vitro digestion and after (bioaccessible fraction). Untargeted metabolomic analyses for bioaccessible fractions were performed by UPLC-QTOF. DPPH percentages were 89.7%–90.3%, 90.1%–91.3%, and 90.8%–91.3% in the control, I. orientalis, and P. kudriazevii samples, respectively, before digestion; α-glucosidase inhibition before digestion was 1.9%–24.4%, 16.3%–30.0%, and 21.3%–31.3%, respectively; antimicrobial activities were 6.1%–13.3%, 13.7%–25.7%, and 20.6%–28.0% against E. coli O157:H7 and 2.2%–11.9%, 7.2%–20.7%, and 11.9%–29.2% against L. monocytogenes, respectively. The DPPH scavenging percentages were ∼63% lower in the bioaccessible fraction. The differentially regulated metabolites classes were benzene and derivatives, amino acids, peptides and analogs, organic acids, and phenols. This study revealed that the fermented DFP exhibited higher health properties than control.

Original languageEnglish
Article number133666
JournalFood Chemistry
Volume396
DOIs
Publication statusPublished - Dec 1 2022

Keywords

  • Antioxidant
  • Cytotoxicity
  • Immunomodulatory
  • In vitro digestion
  • Yeast

ASJC Scopus subject areas

  • Analytical Chemistry
  • Food Science

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