Biocompatibility of calcined mesoporous silica particles with cellular bioenergetics in murine tissues

Mariam Al Shamsi; Mohammed T. Al Samri; Suhail Al-Salam; Walter Conca; Sami Shaban; Sheela Benedict; Saeed Tariq; Ankush V. Biradar; Harvey S. Penefsky; Tewodros Asefa; Abdul Kader Souid

doi:10.1021/tx100245j

Biocompatibility of calcined mesoporous silica particles with cellular bioenergetics in murine tissues

Mariam Al Shamsi, Mohammed T. Al Samri, Suhail Al-Salam, Walter Conca, Sami Shaban, Sheela Benedict, Saeed Tariq, Ankush V. Biradar, Harvey S. Penefsky, Tewodros Asefa, Abdul Kader Souid

Research output: Contribution to journal › Article › peer-review

32 Citations (Scopus)

Abstract

A novel in vitro system was developed to investigate the effects of two forms of calcined mesoporous silica particles (MCM41-cal and SBA15-cal) on cellular respiration of mouse tissues. O₂ consumption by lung, liver, kidney, spleen, and pancreatic tissues was unaffected by exposure to 200 μg/mL MCM41-cal or SBA15-cal for several hours. Normal tissue histology was confirmed by light microscopy. Intracellular accumulation of the particles in the studied tissues was evident by electron microscopy. The results show reasonable in vitro biocompatibility of the mesoporous silicas with murine tissue bioenergetics.

Original language	English
Pages (from-to)	1796-1805
Number of pages	10
Journal	Chemical Research in Toxicology
Volume	23
Issue number	11
DOIs	https://doi.org/10.1021/tx100245j
Publication status	Published - Nov 15 2010

ASJC Scopus subject areas

Toxicology

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title = "Biocompatibility of calcined mesoporous silica particles with cellular bioenergetics in murine tissues",

abstract = "A novel in vitro system was developed to investigate the effects of two forms of calcined mesoporous silica particles (MCM41-cal and SBA15-cal) on cellular respiration of mouse tissues. O2 consumption by lung, liver, kidney, spleen, and pancreatic tissues was unaffected by exposure to 200 μg/mL MCM41-cal or SBA15-cal for several hours. Normal tissue histology was confirmed by light microscopy. Intracellular accumulation of the particles in the studied tissues was evident by electron microscopy. The results show reasonable in vitro biocompatibility of the mesoporous silicas with murine tissue bioenergetics.",

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T1 - Biocompatibility of calcined mesoporous silica particles with cellular bioenergetics in murine tissues

AU - Al Shamsi, Mariam

AU - Al Samri, Mohammed T.

AU - Al-Salam, Suhail

AU - Conca, Walter

AU - Shaban, Sami

AU - Benedict, Sheela

AU - Tariq, Saeed

AU - Biradar, Ankush V.

AU - Penefsky, Harvey S.

AU - Asefa, Tewodros

AU - Souid, Abdul Kader

PY - 2010/11/15

Y1 - 2010/11/15

N2 - A novel in vitro system was developed to investigate the effects of two forms of calcined mesoporous silica particles (MCM41-cal and SBA15-cal) on cellular respiration of mouse tissues. O2 consumption by lung, liver, kidney, spleen, and pancreatic tissues was unaffected by exposure to 200 μg/mL MCM41-cal or SBA15-cal for several hours. Normal tissue histology was confirmed by light microscopy. Intracellular accumulation of the particles in the studied tissues was evident by electron microscopy. The results show reasonable in vitro biocompatibility of the mesoporous silicas with murine tissue bioenergetics.

AB - A novel in vitro system was developed to investigate the effects of two forms of calcined mesoporous silica particles (MCM41-cal and SBA15-cal) on cellular respiration of mouse tissues. O2 consumption by lung, liver, kidney, spleen, and pancreatic tissues was unaffected by exposure to 200 μg/mL MCM41-cal or SBA15-cal for several hours. Normal tissue histology was confirmed by light microscopy. Intracellular accumulation of the particles in the studied tissues was evident by electron microscopy. The results show reasonable in vitro biocompatibility of the mesoporous silicas with murine tissue bioenergetics.

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Biocompatibility of calcined mesoporous silica particles with cellular bioenergetics in murine tissues

Abstract

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