TY - JOUR
T1 - Biological and pharmacological effects and nutritional impact of phytosterols
T2 - A comprehensive review
AU - Nattagh-Eshtivani, Elyas
AU - Barghchi, Hanieh
AU - Pahlavani, Naseh
AU - Barati, Mehdi
AU - Amiri, Yasaman
AU - Fadel, Abdulmannan
AU - Khosravi, Maryam
AU - Talebi, Saeedeh
AU - Arzhang, Pishva
AU - Ziaei, Rahele
AU - Ghavami, Abed
N1 - Publisher Copyright:
© 2021 John Wiley & Sons Ltd.
PY - 2022/1
Y1 - 2022/1
N2 - Phytosterols (PSs), classified into plant sterols and stanols, are bioactive compounds found in foods of plant origin. PSs have been proposed to exert a wide number of pharmacological properties, including the potential to reduce total and low-density lipoprotein (LDL) cholesterol levels and thereby decreasing the risk of cardiovascular diseases. Other health-promoting effects of PSs include anti-obesity, anti-diabetic, anti-microbial, anti-inflammatory, and immunomodulatory effects. Also, anticancer effects have been strongly suggested, as phytosterol-rich diets may reduce the risk of cancer by 20%. The aim of this review is to provide a general overview of the available evidence regarding the beneficial physiological and pharmacological activities of PSs, with special emphasis on their therapeutic potential for human health and safety. Also, we will explore the factors that influence the physiologic response to PSs.
AB - Phytosterols (PSs), classified into plant sterols and stanols, are bioactive compounds found in foods of plant origin. PSs have been proposed to exert a wide number of pharmacological properties, including the potential to reduce total and low-density lipoprotein (LDL) cholesterol levels and thereby decreasing the risk of cardiovascular diseases. Other health-promoting effects of PSs include anti-obesity, anti-diabetic, anti-microbial, anti-inflammatory, and immunomodulatory effects. Also, anticancer effects have been strongly suggested, as phytosterol-rich diets may reduce the risk of cancer by 20%. The aim of this review is to provide a general overview of the available evidence regarding the beneficial physiological and pharmacological activities of PSs, with special emphasis on their therapeutic potential for human health and safety. Also, we will explore the factors that influence the physiologic response to PSs.
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U2 - 10.1002/ptr.7312
DO - 10.1002/ptr.7312
M3 - Review article
C2 - 34729825
AN - SCOPUS:85118501644
SN - 0951-418X
VL - 36
SP - 299
EP - 322
JO - Phytotherapy Research
JF - Phytotherapy Research
IS - 1
ER -
