Biomedical properties of edible seaweed in cancer therapy and chemoprevention trials: A review

Farideh Namvar, Paridah Md Tahir, Rosfarizan Mohamad, Mahnaz Mahdavi, Parvin Abedi, Tahereh Fathi Najafi, Heshu Sulaiman Rahman, Mohammad Jawaid

Research output: Contribution to journalReview articlepeer-review

20 Citations (Scopus)

Abstract

This review article summarizes in vitro and in vivo experiments on seaweed anticancer activity and seaweed chemical components. Seaweed use in cancer therapy, chemopreventive randomized control trials (RCTs) and quasi-experiments are discussed. The literature reviewed in this article was obtained from various scientific sources and encompasses publications from 2000-2012. Seaweed therapeutic effects were deemed scientifically plausible and may be partially explained by the in vivo and in vitro pharmacological studies described. Although the mechanisms of action remain unclear, seaweed's anticancer properties may be attributable to its major biologically active metabolites. Much of the seaweed research outlined in this paper can serve as a foundation for explaining seaweed anticancer bioactivity. This review will open doors for developing strategies to treat malignancies using seaweed natural products.

Original languageEnglish
Pages (from-to)1811-1820
Number of pages10
JournalNatural Product Communications
Volume8
Issue number12
DOIs
Publication statusPublished - Dec 2013
Externally publishedYes

Keywords

  • Anticancer
  • Apoptosis
  • Cancer therapy
  • Chemoprevention
  • Cytotoxicity
  • Macro algae
  • Seaweeds

ASJC Scopus subject areas

  • Pharmacology
  • Plant Science
  • Drug Discovery
  • Complementary and alternative medicine

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