TY - JOUR
T1 - BioMOF-Based Anti-Cancer Drug Delivery Systems
AU - Elmehrath, Sandy
AU - Nguyen, Ha L.
AU - Karam, Sherif M.
AU - Amin, Amr
AU - Greish, Yaser E.
N1 - Funding Information:
This research was funded by the United Arab Emirates University and Zayed Centre for Health Sciences.
Funding Information:
We acknowledge the financial support from United Arab Emirates University (UAEU, Grant Code G00003253 with fund code 31R236) and the support of the UAEU Zayed Centre for Health Sciences (UAEU-ZCHS).
Publisher Copyright:
© 2023 by the authors.
PY - 2023/3
Y1 - 2023/3
N2 - A variety of nanomaterials have been developed specifically for biomedical applications, such as drug delivery in cancer treatment. These materials involve both synthetic and natural nanoparticles and nanofibers of varying dimensions. The efficacy of a drug delivery system (DDS) depends on its biocompatibility, intrinsic high surface area, high interconnected porosity, and chemical functionality. Recent advances in metal-organic framework (MOF) nanostructures have led to the achievement of these desirable features. MOFs consist of metal ions and organic linkers that are assembled in different geometries and can be produced in 0, 1, 2, or 3 dimensions. The defining features of MOFs are their outstanding surface area, interconnected porosity, and variable chemical functionality, which enable an endless range of modalities for loading drugs into their hierarchical structures. MOFs, coupled with biocompatibility requisites, are now regarded as highly successful DDSs for the treatment of diverse diseases. This review aims to present the development and applications of DDSs based on chemically-functionalized MOF nanostructures in the context of cancer treatment. A concise overview of the structure, synthesis, and mode of action of MOF-DDS is provided.
AB - A variety of nanomaterials have been developed specifically for biomedical applications, such as drug delivery in cancer treatment. These materials involve both synthetic and natural nanoparticles and nanofibers of varying dimensions. The efficacy of a drug delivery system (DDS) depends on its biocompatibility, intrinsic high surface area, high interconnected porosity, and chemical functionality. Recent advances in metal-organic framework (MOF) nanostructures have led to the achievement of these desirable features. MOFs consist of metal ions and organic linkers that are assembled in different geometries and can be produced in 0, 1, 2, or 3 dimensions. The defining features of MOFs are their outstanding surface area, interconnected porosity, and variable chemical functionality, which enable an endless range of modalities for loading drugs into their hierarchical structures. MOFs, coupled with biocompatibility requisites, are now regarded as highly successful DDSs for the treatment of diverse diseases. This review aims to present the development and applications of DDSs based on chemically-functionalized MOF nanostructures in the context of cancer treatment. A concise overview of the structure, synthesis, and mode of action of MOF-DDS is provided.
KW - BioMOFs
KW - cancer treatment
KW - chemical modification
KW - drug delivery
KW - metal–organic frameworks
KW - nanostructures
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U2 - 10.3390/nano13050953
DO - 10.3390/nano13050953
M3 - Review article
AN - SCOPUS:85149753229
SN - 2079-4991
VL - 13
JO - Nanomaterials
JF - Nanomaterials
IS - 5
M1 - 953
ER -
