BioMOF-Based Anti-Cancer Drug Delivery Systems

Sandy Elmehrath, Ha L. Nguyen, Sherif M. Karam, Amr Amin, Yaser E. Greish

Research output: Contribution to journalReview articlepeer-review

11 Citations (Scopus)

Abstract

A variety of nanomaterials have been developed specifically for biomedical applications, such as drug delivery in cancer treatment. These materials involve both synthetic and natural nanoparticles and nanofibers of varying dimensions. The efficacy of a drug delivery system (DDS) depends on its biocompatibility, intrinsic high surface area, high interconnected porosity, and chemical functionality. Recent advances in metal-organic framework (MOF) nanostructures have led to the achievement of these desirable features. MOFs consist of metal ions and organic linkers that are assembled in different geometries and can be produced in 0, 1, 2, or 3 dimensions. The defining features of MOFs are their outstanding surface area, interconnected porosity, and variable chemical functionality, which enable an endless range of modalities for loading drugs into their hierarchical structures. MOFs, coupled with biocompatibility requisites, are now regarded as highly successful DDSs for the treatment of diverse diseases. This review aims to present the development and applications of DDSs based on chemically-functionalized MOF nanostructures in the context of cancer treatment. A concise overview of the structure, synthesis, and mode of action of MOF-DDS is provided.

Original languageEnglish
Article number953
JournalNanomaterials
Volume13
Issue number5
DOIs
Publication statusPublished - Mar 2023

Keywords

  • BioMOFs
  • cancer treatment
  • chemical modification
  • drug delivery
  • metal–organic frameworks
  • nanostructures

ASJC Scopus subject areas

  • General Chemical Engineering
  • General Materials Science

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