TY - JOUR
T1 - Bipolar I and II versus unipolar depression
T2 - Clinical differences and impulsivity/aggression traits
AU - Dervic, K.
AU - Garcia-Amador, M.
AU - Sudol, K.
AU - Freed, P.
AU - Brent, D. A.
AU - Mann, J. J.
AU - Harkavy-Friedman, J. M.
AU - Oquendo, M. A.
N1 - Funding Information:
Drs. Dervic, Garcia-Amador, Freed, Harkavy-Freedman, Sudol have nothing to disclose. Dr. Brent reports grants from NIMH, during the conduct of the study; personal fees from UPMC, Western Psychiatric Institute and Clinic, University of Pittsburgh; grants from NIMH; personal fees from Continuing Medical Education events; personal fees from Oxford Press; personal fees from Guilford Press; ERT, Inc., personal fees from CME Presentations, personal fees from UptoDate, outside the submitted work. Dr. Mann reports grants from GSK, grants from Novartis, outside the submitted work. In addition, Dr. Mann has patent royalties from commercial use of C-SSRS from Research Foundation for Mental Health with royalties paid. Dr. Oquendo reports other from Pfizer, grants from Astra-Zeneca, Bristol Myers Squibb, Eli Lilly, Janssen, Otsuko, Pfizer, Sanofi-Aventis, and Shire; other from Columbia Suicide Severity Rating Scale; other from Stock/stock options; other from Travel/accommodations/meeting expenses unrelated to activities listed, outside the submitted work.
Publisher Copyright:
© 2014.
PY - 2015/1/1
Y1 - 2015/1/1
N2 - Objective: To investigate distinguishing features between bipolar I, II and unipolar depression, and impulsivity/aggression traits in particular. Methods: Six hundred and eighty-five (n=. 685) patients in a major depressive episode with lifetime Unipolar (UP) depression (n=. 455), Bipolar I (BP-I) disorder (n=. 151), and Bipolar II (BP-II) (n=. 79) disorder were compared in terms of their socio-demographic and clinical characteristics. Results: Compared to unipolar patients, BP-I and BP-II depressed patients were significantly younger at onset of their first depressive episode, and were more likely to experience their first depressive episode before/at age of 15. They also had more previous affective episodes, more first- and second-degree relatives with history of mania, more current psychotic and subsyndromal manic symptoms, and received psychopharmacological and psychotherapy treatment at an earlier age. Furthermore, BP-I and BP-II depressed patients had higher lifetime impulsivity, aggression, and hostility scores. With regard to bipolar subtypes, BP-I patients had more trait-impulsivity and lifetime aggression than BP-II patients whereas the latter had more hostility than BP-I patients. As for co-morbid disorders, Cluster A and B Personality Disorders, alcohol and substance abuse/dependence and anxiety disorders were more prevalent in BP-I and BP-II than in unipolar patients. Whereas the three groups did not differ on other socio-demographic variables, BP-I patients were significantly more often unemployed that UP patients. Conclusion: Our findings comport with major previous findings on differences between bipolar and unipolar depression. As for trait characteristics, bipolar I and II depressed patients had more life-time impulsivity and aggression/hostility than unipolar patients. In addition, bipolar I and II patients also differed on these trait characteristics.
AB - Objective: To investigate distinguishing features between bipolar I, II and unipolar depression, and impulsivity/aggression traits in particular. Methods: Six hundred and eighty-five (n=. 685) patients in a major depressive episode with lifetime Unipolar (UP) depression (n=. 455), Bipolar I (BP-I) disorder (n=. 151), and Bipolar II (BP-II) (n=. 79) disorder were compared in terms of their socio-demographic and clinical characteristics. Results: Compared to unipolar patients, BP-I and BP-II depressed patients were significantly younger at onset of their first depressive episode, and were more likely to experience their first depressive episode before/at age of 15. They also had more previous affective episodes, more first- and second-degree relatives with history of mania, more current psychotic and subsyndromal manic symptoms, and received psychopharmacological and psychotherapy treatment at an earlier age. Furthermore, BP-I and BP-II depressed patients had higher lifetime impulsivity, aggression, and hostility scores. With regard to bipolar subtypes, BP-I patients had more trait-impulsivity and lifetime aggression than BP-II patients whereas the latter had more hostility than BP-I patients. As for co-morbid disorders, Cluster A and B Personality Disorders, alcohol and substance abuse/dependence and anxiety disorders were more prevalent in BP-I and BP-II than in unipolar patients. Whereas the three groups did not differ on other socio-demographic variables, BP-I patients were significantly more often unemployed that UP patients. Conclusion: Our findings comport with major previous findings on differences between bipolar and unipolar depression. As for trait characteristics, bipolar I and II depressed patients had more life-time impulsivity and aggression/hostility than unipolar patients. In addition, bipolar I and II patients also differed on these trait characteristics.
KW - Aggression
KW - Impulsivity
KW - Mood
KW - Personality disorder
KW - Substance abuse
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U2 - 10.1016/j.eurpsy.2014.06.005
DO - 10.1016/j.eurpsy.2014.06.005
M3 - Article
C2 - 25280430
AN - SCOPUS:84920937600
SN - 0924-9338
VL - 30
SP - 106
EP - 113
JO - European Psychiatry
JF - European Psychiatry
IS - 1
ER -