TY - JOUR
T1 - Bolstering the Prognostic Utility of Coronary Risk Assessments with PAI
T2 - A Physical Activity Metric
AU - Nauman, Javaid
AU - Mirzaamin, Tania
AU - Franklin, Barry A.
AU - Nes, Bjarne M.
AU - Lavie, Carl J.
AU - Dunn, Patrick
AU - Arena, Ross
AU - Wen, Chi Pang
AU - Tari, Atefe R.
AU - Wisløff, Ulrik
N1 - Publisher Copyright:
Copyright © 2024 American College of Sports Medicine.
PY - 2024
Y1 - 2024
N2 - Purpose Personal Activity Intelligence (PAI) translates heart rate during physical activity (PA) into a weekly score, that credits vigorous over low-and moderate intensity PA. We prospectively investigated the association between PAI and fatal and non-fatal coronary heart disease (CHD) in self-reported healthy participants from Norway, with specific reference to improving the accuracy of conventional coronary risk assessment. Methods We studied 40 961 healthy adults (56% women) from the population based Trøndelag Health Study (the HUNT study). Individual data were linked to hospital and cause of death registries. The weekly PAI score of each participant was divided into four groups (PAI scores of 0, ≤50, 51-99, or ≥ 100). Adjusted hazard ratios [aHRs] and 95% confidence intervals (CIs) for fatal and non-fatal CHD related to PAI were estimated using Cox proportional hazard regression analyses. Results During a median follow-up period of 13.1 years (IQR, 12.7-13.6), 3303 (3109 non-fatal, 194 fatal) CHD events occurred. Compared with the inactive group (0 PAI), weekly PAI scores at baseline of 51-99 and ≥ 100 were associated with a lower risk of CHD [0.80 (0.71-0.91) and 0.86 (0.78-0.95), respectively]. By adding PAI to traditional risk factors, the net reclassification improvement of CHD was 0.472 (P < 0.001). Conclusions PAI was inversely associated with CHD risk among healthy participants at baseline, and it's cardioprotective effect persisted across diverse risk factor profiles. A PAI score > 50 was substantially associated with a reduced risk of CHD. These findings have implications for improving the accuracy of conventional coronary risk assessments with PAI.
AB - Purpose Personal Activity Intelligence (PAI) translates heart rate during physical activity (PA) into a weekly score, that credits vigorous over low-and moderate intensity PA. We prospectively investigated the association between PAI and fatal and non-fatal coronary heart disease (CHD) in self-reported healthy participants from Norway, with specific reference to improving the accuracy of conventional coronary risk assessment. Methods We studied 40 961 healthy adults (56% women) from the population based Trøndelag Health Study (the HUNT study). Individual data were linked to hospital and cause of death registries. The weekly PAI score of each participant was divided into four groups (PAI scores of 0, ≤50, 51-99, or ≥ 100). Adjusted hazard ratios [aHRs] and 95% confidence intervals (CIs) for fatal and non-fatal CHD related to PAI were estimated using Cox proportional hazard regression analyses. Results During a median follow-up period of 13.1 years (IQR, 12.7-13.6), 3303 (3109 non-fatal, 194 fatal) CHD events occurred. Compared with the inactive group (0 PAI), weekly PAI scores at baseline of 51-99 and ≥ 100 were associated with a lower risk of CHD [0.80 (0.71-0.91) and 0.86 (0.78-0.95), respectively]. By adding PAI to traditional risk factors, the net reclassification improvement of CHD was 0.472 (P < 0.001). Conclusions PAI was inversely associated with CHD risk among healthy participants at baseline, and it's cardioprotective effect persisted across diverse risk factor profiles. A PAI score > 50 was substantially associated with a reduced risk of CHD. These findings have implications for improving the accuracy of conventional coronary risk assessments with PAI.
KW - ACTIVITY METRIC
KW - COHORT
KW - CORONARY HEART DISEASE
KW - EXERCISE
KW - MYOCARDIAL INFARCTION
KW - PHYSICAL ACTIVITY
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U2 - 10.1249/MSS.0000000000003584
DO - 10.1249/MSS.0000000000003584
M3 - Article
AN - SCOPUS:85209064767
SN - 0195-9131
JO - Medicine and Science in Sports and Exercise
JF - Medicine and Science in Sports and Exercise
M1 - 10.1249/MSS.0000000000003584
ER -