TY - JOUR
T1 - Bone marrow morphology during alpha‐interferon treatment in hairy cell leukemia
AU - Hassan, Inaam Bashir
AU - Sundström, Christer
AU - Hagberg, Hans
PY - 1989/8
Y1 - 1989/8
N2 - 14 patients with HCL were started on α‐interferon (IFN) treatment. Bone marrow changes were followed in trephine biopsies every 3rd month. Differential counting was performed according to the point counting method and fiber content was evaluated. At the start of treatment all patients had 80% or more of tumor cells in the bone marrow. The reduction of granulopoiesis was more pronounced than for erythropoie‐sis. During treatment cellularity decreased in 6/13 patients already after 3 months; later, cellularity was normalized in most patients. Only 1 patient showed a complete remission. 12/14 patients showed a significant but slow reduction of tumor cells. Also, between 12 and 18 months an improvement was seen in some patients. The megakaryocytes improved rapidly and the erythropoiesis was normalized before the granulopoiesis. Only 1 patient did not show a bone marrow response. 5/14 patients showed a reduction of bone marrow fibers, first seen after 6 months of treatment. IFN was discontinued in 9/14 patients. 7 of these relapsed during the observation period (18 months).
AB - 14 patients with HCL were started on α‐interferon (IFN) treatment. Bone marrow changes were followed in trephine biopsies every 3rd month. Differential counting was performed according to the point counting method and fiber content was evaluated. At the start of treatment all patients had 80% or more of tumor cells in the bone marrow. The reduction of granulopoiesis was more pronounced than for erythropoie‐sis. During treatment cellularity decreased in 6/13 patients already after 3 months; later, cellularity was normalized in most patients. Only 1 patient showed a complete remission. 12/14 patients showed a significant but slow reduction of tumor cells. Also, between 12 and 18 months an improvement was seen in some patients. The megakaryocytes improved rapidly and the erythropoiesis was normalized before the granulopoiesis. Only 1 patient did not show a bone marrow response. 5/14 patients showed a reduction of bone marrow fibers, first seen after 6 months of treatment. IFN was discontinued in 9/14 patients. 7 of these relapsed during the observation period (18 months).
KW - alpha‐interferon
KW - bone marrow
KW - hairy cell leukemia
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U2 - 10.1111/j.1600-0609.1989.tb00267.x
DO - 10.1111/j.1600-0609.1989.tb00267.x
M3 - Review article
C2 - 2792319
AN - SCOPUS:0024457282
SN - 0902-4441
VL - 43
SP - 120
EP - 126
JO - European Journal of Haematology
JF - European Journal of Haematology
IS - 2
ER -