Brain parenchymal TNF-α and IL-1β induction in experimental pneumococcal meningitis

Kaywan Izadpanah, Dorette Freyer, Joerg R. Weber, Johann S. Braun

Research output: Contribution to journalArticlepeer-review

18 Citations (Scopus)

Abstract

Triggers of brain inflammation in pneumococcal meningitis are unknown. TNF-α and IL-1β were upregulated (real time PCR and in situ hybridization) in neurons and astrocytes time-dependently and maximally in the hippocampus during murine pneumococcal meningitis. Upregulation of TNF-α and IL-1β mRNA in the brain parenchyma was independent of cerebrospinal fluid leukocytosis, pneumococcal pneumolysin and H2O2, but it was potently induced by pneumococcal cell wall (PCW) fragments. Brain TNF-α mRNA was downregulated by a matrix metalloproteinases inhibitor. PCW fragments were located in the brain parenchyma. In conclusion, PCW fragments and matrix metalloproteinases trigger cytokine induction in the brain parenchyma during pneumococcal meningitis.

Original languageEnglish
Pages (from-to)104-111
Number of pages8
JournalJournal of Neuroimmunology
Volume276
Issue number1-2
DOIs
Publication statusPublished - Nov 15 2014
Externally publishedYes

Keywords

  • Brain
  • IL-1β
  • Meningitis
  • Pneumococcal cell wall
  • S. pneumoniae
  • TNF-α

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

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