Brain–Computer Interfaces for Communication in Patients with Disorders of Consciousness: A Gap Analysis and Scientific Roadmap

Nicholas D. Schiff, Michael Diringer, Karin Diserens, Brian L. Edlow, Olivia Gosseries, N. Jeremy Hill, Leigh R. Hochberg, Fatima Y. Ismail, Ivo A. Meyer, Charles B. Mikell, Sima Mofakham, Erika Molteni, Leonard Polizzotto, Sudhin A. Shah, Robert D. Stevens, Daniel Thengone

Research output: Contribution to journalArticlepeer-review

Abstract

Background: We developed a gap analysis that examines the role of brain–computer interfaces (BCI) in patients with disorders of consciousness (DoC), focusing on their assessment, establishment of communication, and engagement with their environment. Methods: The Curing Coma Campaign convened a Coma Science work group that included 16 clinicians and neuroscientists with expertise in DoC. The work group met online biweekly and performed a gap analysis of the primary question. Results: We outline a roadmap for assessing BCI readiness in patients with DoC and for advancing the use of BCI devices in patients with DoC. Additionally, we discuss preliminary studies that inform development of BCI solutions for communication and assessment of readiness for use of BCIs in DoC study participants. Special emphasis is placed on the challenges posed by the complex pathophysiologies caused by heterogeneous brain injuries and their impact on neuronal signaling. The differences between one-way and two-way communication are specifically considered. Possible implanted and noninvasive BCI solutions for acute and chronic DoC in adult and pediatric populations are also addressed. Conclusions: We identify clinical and technical gaps hindering the use of BCI in patients with DoC in each of these contexts and provide a roadmap for research aimed at improving communication for adults and children with DoC, spanning the clinical spectrum from intensive care unit to chronic care.

Original languageEnglish
JournalNeurocritical Care
DOIs
Publication statusAccepted/In press - 2024

Keywords

  • Cognitive motor dissociation
  • Coma
  • Communication
  • Electroencephalography
  • Functional magnetic resonance imaging
  • Head injury
  • Neural repair

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine
  • Clinical Neurology

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