Burden of non-communicable disease studies in Europe: a systematic review of data sources and methodological choices

Periklis Charalampous, Vanessa Gorasso, Dietrich Plass, Sara M. Pires, Elena Von Der Lippe, Alibek Mereke, Jane Idavain, Katarzyna Kissimova-Skarbek, Joana Nazare Morgado, Che Henry Ngwa, Isabel Noguer, Alicia Padron-Monedero, María Jose Santi-Cano, Rodrigo Sarmiento, Brecht Devleesschauwer, Juanita A. Haagsma, Balázs Ádám, Ala'a Alkerwi, Boris Bikbov, Anette Kocbach BøllingSusanne Breitner, Sarah Cuschieri, Christina C. Dahm, Terje Andreas Eikemo, Florian Fischer, Alberto Freitas, Juan Manuel García-González, Federica Gazzelloni, Mika Gissler, Brigita Hengl, Paul Hynds, Gaetano Isola, Lea S. Jakobsen, Zubair Kabir, Ann Kristin Knudsen, Naime Meriç Konar, Carina Ladeira, Aaron Liew, Marjeta Majer, Enkeleint A. Mechili, Vildan Mevsim, Milena Santric Milicevic, Louise Mitchell, Lorenzo Monasta, Stefania Mondello, Evangelia Nena, Edmond S.W. Ng, Vikram Niranjan, Rónán O'Caoimh, Mark Ryan O'Donovan, Alberto Ortiz, Elena Pallari, Panagiotis Petrou, Miguel Reina Ortiz, Silvia Riva, Hanène Samouda, João V. Santos, Cornelia Melinda Adi Santoso, Tugce Schmitt, Dimitrios Skempes, Ana Catarina Sousa, Aleksandar Stevanovic, Gerhard Sulo Natasa Terzic, Zorica Terzic-Supic, Jovana Todorovic, Fimka Tozija, Brigid Unim, Lisa Van Wilder, Orsolya Varga, Francesco S. Violante, Grant M.A. Wyper

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)


Background: Assessment of disability-adjusted life years (DALYs) resulting from non-communicable diseases (NCDs) requires specific calculation methods and input data. The aims of this study were to (i) identify existing NCD burden of disease (BoD) activities in Europe; (ii) collate information on data sources for mortality and morbidity; and (iii) provide an overview of NCD-specific methods for calculating NCD DALYs. Methods: NCD BoD studies were systematically searched in international electronic literature databases and in grey literature. We included all BoD studies that used the DALY metric to quantify the health impact of one or more NCDs in countries belonging to the European Region. Results: A total of 163 BoD studies were retained: 96 (59%) were single-country or sub-national studies and 67 (41%) considered more than one country. Of the single-country studies, 29 (30%) consisted of secondary analyses using existing Global Burden of Disease (GBD) results. Mortality data were mainly derived (49%) from vital statistics. Morbidity data were frequently (40%) drawn from routine administrative and survey datasets, including disease registries and hospital discharge databases. The majority (60%) of national BoD studies reported mortality corrections. Multimorbidity adjustments were performed in 18% of national BoD studies. Conclusion: The number of national NCD BoD assessments across Europe increased over time, driven by an increase in BoD studies that consisted of secondary data analysis of GBD study findings. Ambiguity in reporting the use of NCD-specific BoD methods underlines the need for reporting guidelines of BoD studies to enhance the transparency of NCD BoD estimates across Europe.

Original languageEnglish
Pages (from-to)289-296
Number of pages8
JournalEuropean Journal of Public Health
Issue number2
Publication statusPublished - Apr 1 2022

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health


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