Caerulein-induced Pancreatitis in Wistar Rats

Glenn Farrant; Fikri M. Abu-Zidan; Xusheng Liu; L. Jonathan Zwi; John A. Windsor

Caerulein-induced Pancreatitis in Wistar Rats

Glenn Farrant, Fikri M. Abu-Zidan, Xusheng Liu, L. Jonathan Zwi, John A. Windsor

Research output: Contribution to journal › Article › peer-review

Abstract

We describe a refined model of intravenous caerulein-induced pancreatitis by using osmotic infusion pumps in the conscious unrestrained Wistar rat. The volume of caerulein required for the 6-h infusion is loaded into PE-55 catheter tubing attached to an Alzet (Alza Corporation, Palo Alto, CA) implantable osmotic pump that has been primed with saline. The technique has reliably induced mild edematous pancreatitis, which we verified histologically. Our refined model has the advantages of unrestrained animals, reduced animal handling and acclimation, and decreased cost.

Original language	English
Pages (from-to)	36-39
Number of pages	4
Journal	Contemporary Topics in Laboratory Animal Science
Volume	39
Issue number	4
Publication status	Published - Jul 2000
Externally published	Yes

ASJC Scopus subject areas

Animal Science and Zoology
General Veterinary

Cite this

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AU - Windsor, John A.

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AB - We describe a refined model of intravenous caerulein-induced pancreatitis by using osmotic infusion pumps in the conscious unrestrained Wistar rat. The volume of caerulein required for the 6-h infusion is loaded into PE-55 catheter tubing attached to an Alzet (Alza Corporation, Palo Alto, CA) implantable osmotic pump that has been primed with saline. The technique has reliably induced mild edematous pancreatitis, which we verified histologically. Our refined model has the advantages of unrestrained animals, reduced animal handling and acclimation, and decreased cost.

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Caerulein-induced Pancreatitis in Wistar Rats

Abstract

ASJC Scopus subject areas

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