Calcium selective polymeric membranes for microfabricated sensor arrays

Vasile V. Cosofret, Wendi Weirauch Olson, Sayed A.M. Marzouk, Miklos Erdosy, Timothy A. Johnson, Richard P. Buck

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)


The potentiometric and impedance characteristics of various selective Ca2+ polymeric membranes are described and interpreted by theory and experiments for Ca2+ microfabricated sensor arrays. These are designed for further biomedical applications with an emphasis on potential in situ applications. The polymeric materials used in the present studies consist of either carboxylated PVC or aliphatic polyurethane. Both materials showed good adherence properties to the polyimide-coated Kapton substrate used in planar sensor fabrication. The impedance analysis, performed in the frequency range from 65,000 Hz to 0.1 Hz, revealed the bulk geometrical response at high frequencies. Measured Rbulk corresponds to the unperturbed bulk resistance. That, in turn, depends on mobilities and concentrations of Ca2+ complex and mobile sites. Decreases in Rbulk correlated well with sensor behavior during the preconditioning (hydration) period. Studies of blood interactions with these sensors proved that the main sensor characteristics (Eo, slope of the calibration curve, and reproducibility of response) are not significantly affected after 14 days of whole blood contact.

Original languageEnglish
Pages (from-to)725-743
Number of pages19
JournalAnalytical Letters
Issue number5
Publication statusPublished - 1996
Externally publishedYes


  • Blood interactions with sensor materials
  • Calcium planar microchemical sensor arrays
  • Impedance analysis
  • Polymeric membranes

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Spectroscopy
  • Clinical Biochemistry
  • Biochemistry, medical
  • Electrochemistry


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