Calcium signaling in the ventricular myocardium of the Goto-Kakizaki type 2 diabetic rat

L. Al Kury; M. Smail; M. A. Qureshi; V. Sydorenko; A. Shmygol; M. Oz; J. Singh; F. C. Howarth

doi:10.1155/2018/2974304

Calcium signaling in the ventricular myocardium of the Goto-Kakizaki type 2 diabetic rat

L. Al Kury, M. Smail, M. A. Qureshi, V. Sydorenko, A. Shmygol, M. Oz, J. Singh, F. C. Howarth

Research output: Contribution to journal › Review article › peer-review

10 Citations (Scopus)

Abstract

The association between diabetes mellitus (DM) and high mortality linked to cardiovascular disease (CVD) is a major concern worldwide. Clinical and preclinical studies have demonstrated a variety of diastolic and systolic dysfunctions in patients with type 2 diabetes mellitus (T2DM) with the severity of abnormalities depending on the patients' age and duration of diabetes. The cellular basis of hemodynamic dysfunction in a type 2 diabetic heart is still not well understood. The aim of this review is to evaluate our current understanding of contractile dysfunction and disturbances of Ca²⁺ transport in the Goto-Kakizaki (GK) diabetic rat heart. The GK rat is a widely used nonobese, nonhypertensive genetic model of T2DM which is characterized by insulin resistance, elevated blood glucose, alterations in blood lipid profile, and cardiac dysfunction.

Original language	English
Article number	2974304
Journal	Journal of Diabetes Research
Volume	2018
DOIs	https://doi.org/10.1155/2018/2974304
Publication status	Published - 2018

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Endocrinology

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title = "Calcium signaling in the ventricular myocardium of the Goto-Kakizaki type 2 diabetic rat",

abstract = "The association between diabetes mellitus (DM) and high mortality linked to cardiovascular disease (CVD) is a major concern worldwide. Clinical and preclinical studies have demonstrated a variety of diastolic and systolic dysfunctions in patients with type 2 diabetes mellitus (T2DM) with the severity of abnormalities depending on the patients' age and duration of diabetes. The cellular basis of hemodynamic dysfunction in a type 2 diabetic heart is still not well understood. The aim of this review is to evaluate our current understanding of contractile dysfunction and disturbances of Ca2+ transport in the Goto-Kakizaki (GK) diabetic rat heart. The GK rat is a widely used nonobese, nonhypertensive genetic model of T2DM which is characterized by insulin resistance, elevated blood glucose, alterations in blood lipid profile, and cardiac dysfunction.",

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AU - Al Kury, L.

AU - Smail, M.

AU - Qureshi, M. A.

AU - Sydorenko, V.

AU - Shmygol, A.

AU - Oz, M.

AU - Singh, J.

AU - Howarth, F. C.

PY - 2018

Y1 - 2018

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AB - The association between diabetes mellitus (DM) and high mortality linked to cardiovascular disease (CVD) is a major concern worldwide. Clinical and preclinical studies have demonstrated a variety of diastolic and systolic dysfunctions in patients with type 2 diabetes mellitus (T2DM) with the severity of abnormalities depending on the patients' age and duration of diabetes. The cellular basis of hemodynamic dysfunction in a type 2 diabetic heart is still not well understood. The aim of this review is to evaluate our current understanding of contractile dysfunction and disturbances of Ca2+ transport in the Goto-Kakizaki (GK) diabetic rat heart. The GK rat is a widely used nonobese, nonhypertensive genetic model of T2DM which is characterized by insulin resistance, elevated blood glucose, alterations in blood lipid profile, and cardiac dysfunction.

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Calcium signaling in the ventricular myocardium of the Goto-Kakizaki type 2 diabetic rat

Abstract

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