Camel milk lactoferrin reduces the proliferation of colorectal cancer cells and exerts antioxidant and DNA damage inhibitory activities

Hosam M. Habib; Wissam H. Ibrahim; Regine Schneider-Stock; Hassan M. Hassan

doi:10.1016/j.foodchem.2013.03.039

Camel milk lactoferrin reduces the proliferation of colorectal cancer cells and exerts antioxidant and DNA damage inhibitory activities

Hosam M. Habib
, Wissam H. Ibrahim
, Regine Schneider-Stock
, Hassan M. Hassan

Nutrition and Health (CMHS)

Research output: Contribution to journal › Article › peer-review

164 Citations (Scopus)

Abstract

Lactoferrin (Lf), the main iron-binding protein of milk, has biological activities. We have evaluated the potential of camel milk lactoferrin for its ability to inhibit the proliferation of the colon cancer cell line, HCT-116, in vitro, DNA damage and its antioxidant activities for the first time. The antioxidant capacity of Lf was evaluated by different assays, including ferric-reducing/antioxidant power assay (FRAP), free radical-scavenging activity (DPPH), nitric oxide (NO) radical-scavenging assay, total antioxidant activity and DNA damage, compared with vitamin C and rutin.

Original language	English
Pages (from-to)	148-152
Number of pages	5
Journal	Food Chemistry
Volume	141
Issue number	1
DOIs	https://doi.org/10.1016/j.foodchem.2013.03.039
Publication status	Published - 2013

Keywords

Camel milk
DNA damage
DPPH
FRAP
HCT-116 colon cancer cells
Lactoferrin

ASJC Scopus subject areas

Analytical Chemistry
Food Science

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10.1016/j.foodchem.2013.03.039

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title = "Camel milk lactoferrin reduces the proliferation of colorectal cancer cells and exerts antioxidant and DNA damage inhibitory activities",

abstract = "Lactoferrin (Lf), the main iron-binding protein of milk, has biological activities. We have evaluated the potential of camel milk lactoferrin for its ability to inhibit the proliferation of the colon cancer cell line, HCT-116, in vitro, DNA damage and its antioxidant activities for the first time. The antioxidant capacity of Lf was evaluated by different assays, including ferric-reducing/antioxidant power assay (FRAP), free radical-scavenging activity (DPPH), nitric oxide (NO) radical-scavenging assay, total antioxidant activity and DNA damage, compared with vitamin C and rutin.",

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T1 - Camel milk lactoferrin reduces the proliferation of colorectal cancer cells and exerts antioxidant and DNA damage inhibitory activities

AU - Habib, Hosam M.

AU - Ibrahim, Wissam H.

AU - Schneider-Stock, Regine

AU - Hassan, Hassan M.

PY - 2013

Y1 - 2013

N2 - Lactoferrin (Lf), the main iron-binding protein of milk, has biological activities. We have evaluated the potential of camel milk lactoferrin for its ability to inhibit the proliferation of the colon cancer cell line, HCT-116, in vitro, DNA damage and its antioxidant activities for the first time. The antioxidant capacity of Lf was evaluated by different assays, including ferric-reducing/antioxidant power assay (FRAP), free radical-scavenging activity (DPPH), nitric oxide (NO) radical-scavenging assay, total antioxidant activity and DNA damage, compared with vitamin C and rutin.

AB - Lactoferrin (Lf), the main iron-binding protein of milk, has biological activities. We have evaluated the potential of camel milk lactoferrin for its ability to inhibit the proliferation of the colon cancer cell line, HCT-116, in vitro, DNA damage and its antioxidant activities for the first time. The antioxidant capacity of Lf was evaluated by different assays, including ferric-reducing/antioxidant power assay (FRAP), free radical-scavenging activity (DPPH), nitric oxide (NO) radical-scavenging assay, total antioxidant activity and DNA damage, compared with vitamin C and rutin.

KW - Camel milk

KW - DNA damage

KW - DPPH

KW - FRAP

KW - HCT-116 colon cancer cells

KW - Lactoferrin

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DO - 10.1016/j.foodchem.2013.03.039

M3 - Article

C2 - 23768340

AN - SCOPUS:84877631392

SN - 0308-8146

VL - 141

SP - 148

EP - 152

JO - Food Chemistry

JF - Food Chemistry

IS - 1

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Camel milk lactoferrin reduces the proliferation of colorectal cancer cells and exerts antioxidant and DNA damage inhibitory activities

Abstract

Keywords

ASJC Scopus subject areas

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