Can misoprostol and omeprazole reduce nicotine and ethanol induced gastric mucosal injury? A quantitative macroscopic and microscopic analysis in rats

W. M. Hui; J. Ho; B. W. Chen; C. H. Cho; F. J. Branicki; S. K. Lam

doi:10.1111/j.1440-1746.1997.tb00337.x

Can misoprostol and omeprazole reduce nicotine and ethanol induced gastric mucosal injury? A quantitative macroscopic and microscopic analysis in rats

W. M. Hui, J. Ho, B. W. Chen, C. H. Cho, F. J. Branicki, S. K. Lam

Research output: Contribution to journal › Article › peer-review

Abstract

We compared the effects of misoprostol, omeprazole and methylcellulose (control) on gastric mucosal injury induced by nicotine and/or ethanol. The results demonstrate that misoprostol and omeprazole each significantly reduce macroscopic injury and deep injury at a microscopic level (P < 0.05) induced by nicotine alone, ethanol alone or a combination of ethanol and nicotine. Misoprostol and omeprazole each reduced the leakage of fluorescein isothiocyanate-albumin into the interstitium in the gastric mucosa. Misoprostol and omeprazole are each effective in preventing injury induced by nicotine and ethanol and vascular factors are involved.

Original language	English
Pages (from-to)	7-12
Number of pages	6
Journal	Journal of Gastroenterology and Hepatology (Australia)
Volume	12
Issue number	1
DOIs	https://doi.org/10.1111/j.1440-1746.1997.tb00337.x
Publication status	Published - 1997
Externally published	Yes

Keywords

Gastric
Macroscopic
Microscopic
Misoprostol
Omeprazole

ASJC Scopus subject areas

Hepatology
Gastroenterology

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10.1111/j.1440-1746.1997.tb00337.x

Cite this

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AU - Chen, B. W.

AU - Cho, C. H.

AU - Branicki, F. J.

AU - Lam, S. K.

PY - 1997

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AB - We compared the effects of misoprostol, omeprazole and methylcellulose (control) on gastric mucosal injury induced by nicotine and/or ethanol. The results demonstrate that misoprostol and omeprazole each significantly reduce macroscopic injury and deep injury at a microscopic level (P < 0.05) induced by nicotine alone, ethanol alone or a combination of ethanol and nicotine. Misoprostol and omeprazole each reduced the leakage of fluorescein isothiocyanate-albumin into the interstitium in the gastric mucosa. Misoprostol and omeprazole are each effective in preventing injury induced by nicotine and ethanol and vascular factors are involved.

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KW - Microscopic

KW - Misoprostol

KW - Omeprazole

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Can misoprostol and omeprazole reduce nicotine and ethanol induced gastric mucosal injury? A quantitative macroscopic and microscopic analysis in rats

Abstract

Keywords

ASJC Scopus subject areas

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