Abstract
We compared the effects of misoprostol, omeprazole and methylcellulose (control) on gastric mucosal injury induced by nicotine and/or ethanol. The results demonstrate that misoprostol and omeprazole each significantly reduce macroscopic injury and deep injury at a microscopic level (P < 0.05) induced by nicotine alone, ethanol alone or a combination of ethanol and nicotine. Misoprostol and omeprazole each reduced the leakage of fluorescein isothiocyanate-albumin into the interstitium in the gastric mucosa. Misoprostol and omeprazole are each effective in preventing injury induced by nicotine and ethanol and vascular factors are involved.
| Original language | English |
|---|---|
| Pages (from-to) | 7-12 |
| Number of pages | 6 |
| Journal | Journal of Gastroenterology and Hepatology (Australia) |
| Volume | 12 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 1997 |
| Externally published | Yes |
Keywords
- Gastric
- Macroscopic
- Microscopic
- Misoprostol
- Omeprazole
ASJC Scopus subject areas
- Hepatology
- Gastroenterology
Fingerprint
Dive into the research topics of 'Can misoprostol and omeprazole reduce nicotine and ethanol induced gastric mucosal injury? A quantitative macroscopic and microscopic analysis in rats'. Together they form a unique fingerprint.Cite this
- APA
- Standard
- Harvard
- Vancouver
- Author
- BIBTEX
- RIS