Carboxymethylated Gums and Derivatization: Strategies and Significance in Drug Delivery and Tissue Engineering

Madhuri Baghel, Kalyani Sakure, Tapan Kumar Giri, Sabyasachi Maiti, Kartik T. Nakhate, Shreesh Ojha, Charu Sharma, Yogeeta Agrawal, Sameer Goyal, Hemant Badwaik

Research output: Contribution to journalReview articlepeer-review

3 Citations (Scopus)

Abstract

Natural polysaccharides have been widely exploited in drug delivery and tissue engineering research. They exhibit excellent biocompatibility and fewer adverse effects; however, it is challenging to assess their bioactivities to that of manufactured synthetics because of their intrinsic physicochemical characteristics. Studies showed that the carboxymethylation of polysaccharides considerably increases the aqueous solubility and bioactivities of inherent polysaccharides and offers structural diversity, but it also has some limitations that can be resolved by derivatization or the grafting of carboxymethylated gums. The swelling ratio, flocculation capacity, viscosity, partition coefficient, metal absorption properties, and thermosensitivity of natural polysaccharides have been improved as a result of these changes. In order to create better and functionally enhanced polysaccharides, researchers have modified the structures and properties of carboxymethylated gums. This review summarizes the various ways of modifying carboxymethylated gums, explores the impact that molecular modifications have on their physicochemical characteristics and bioactivities, and sheds light on various applications for the derivatives of carboxymethylated polysaccharides.

Original languageEnglish
Article number776
JournalPharmaceuticals
Volume16
Issue number5
DOIs
Publication statusPublished - May 2023

Keywords

  • carboxymethylated gums
  • derivatization
  • drug delivery
  • tissue engineering

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmaceutical Science
  • Drug Discovery

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