Cardioprotective effect of root extract of Picrorhiza kurroa (Royle Ex Benth) against isoproterenol-induced cardiotoxicity in rats

Mukesh Nandave, Shreesh Kumar Ojha, Santosh Kumari, Tapas Chandra Nag, Raj Mehra, Rajiv Narang, Dharamvir Singh Arya

Research output: Contribution to journalArticlepeer-review

26 Citations (Scopus)

Abstract

Normal rats pre-treated with P. kurroa (200 mg/kg) alone did not showed significant change, however, isoproterenol (ISP) administration resulted in hemodynamic and left ventricular dysfunction, oxidative stress, and lipid peroxidation. Such cardiac dysfunction was significantly prevented by P. kurroa root extract pre-treatment. Pre-treatment significantly attenuated the ISP-induced oxidative stress by restoring myocardial superoxide dismutase, catalase, and glutathione peroxidase enzymes except reduced glutathione content. P. kurroa pre-treatment markedly attenuated the ISP-induced rise in lipid peroxidation, thereby prevented leakage of myocyte creatine kinase-MB and lactate dehydrogenase enzymes. The results suggest that P. kurroa root extract possesses significant cardioprotective effect, which may be attributed to its antioxidant, anti-peroxidative, and myocardial preservative properties.

Original languageEnglish
Pages (from-to)694-701
Number of pages8
JournalIndian Journal of Experimental Biology
Volume51
Issue number9
Publication statusPublished - 2013
Externally publishedYes

Keywords

  • Hemodynamics
  • Left ventricular dynamics
  • Lipid peroxidation
  • Myocardial injury
  • Oxidative stress

ASJC Scopus subject areas

  • Biotechnology
  • Molecular Biology
  • Cell Biology

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