CCK-8 can inhibit ingestive behavior by acting on the liver

M. Qian, G. S. Wu, A. Adem, A. E. Johnson, P. Södersten

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)


THE possibility that cholecystokinin octapeptide (CCK8) can inhibit ingestive behavior by acting on the liver was investigated. Male rats were trained to ingest an intraorally infused 1M solution of sucrose and then injected with 10 μg CCK-8/kg. Intraperitoneal or hepatic portal vein, but not jugular vein, injection suppressed intake of the sucrose solution. Intraperitoneal injection was more potent than hepatic portal vein injection. Inhibition by hepatic portal vein injection was blocked by i.p. injection of 80 μg/kg of the CCK-A receptor antagonist L-364,718 or by hepatic vagotomy. The results support the hypothesis that CCK-8 can inhibit ingestive behavior via a hormonal action on the liver.

Original languageEnglish
Pages (from-to)359-362
Number of pages4
Issue number2
Publication statusPublished - Feb 5 1999
Externally publishedYes


  • Cholecystokinin
  • Food intake
  • Hormonal action
  • Liver
  • Male rats

ASJC Scopus subject areas

  • General Neuroscience


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