TY - JOUR
T1 - Cellular and molecular targets of menthol actions
AU - Oz, Murat
AU - El Nebrisi, Eslam G.
AU - Yang, Keun Hang S.
AU - Howarth, Frank C.
AU - Al Kury, Lina T.
N1 - Publisher Copyright:
© 2017 Oz, El Nebrisi, Yang, Howarth and Al Kury.
PY - 2017/7/18
Y1 - 2017/7/18
N2 - Menthol belongs to monoterpene class of a structurally diverse group of phytochemicals found in plant-derived essential oils. Menthol is widely used in pharmaceuticals, confectionary, oral hygiene products, pesticides, cosmetics, and as a flavoring agent. In addition, menthol is known to have antioxidant, anti-inflammatory, and analgesic effects. Recently, there has been renewed awareness in comprehending the biological and pharmacological effects of menthol. TRP channels have been demonstrated to mediate the cooling actions of menthol. There has been new evidence demonstrating that menthol can significantly influence the functional characteristics of a number of different kinds of ligand and voltage-gated ion channels, indicating that at least some of the biological and pharmacological effects of menthol can be mediated by alterations in cellular excitability. In this article, we examine the results of earlier studies on the actions of menthol with voltage and ligand-gated ion channels.
AB - Menthol belongs to monoterpene class of a structurally diverse group of phytochemicals found in plant-derived essential oils. Menthol is widely used in pharmaceuticals, confectionary, oral hygiene products, pesticides, cosmetics, and as a flavoring agent. In addition, menthol is known to have antioxidant, anti-inflammatory, and analgesic effects. Recently, there has been renewed awareness in comprehending the biological and pharmacological effects of menthol. TRP channels have been demonstrated to mediate the cooling actions of menthol. There has been new evidence demonstrating that menthol can significantly influence the functional characteristics of a number of different kinds of ligand and voltage-gated ion channels, indicating that at least some of the biological and pharmacological effects of menthol can be mediated by alterations in cellular excitability. In this article, we examine the results of earlier studies on the actions of menthol with voltage and ligand-gated ion channels.
KW - Ligand-gated ion channels
KW - Menthol
KW - Monoterpenes
KW - TRP channels
KW - Voltage-gated ion channels
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U2 - 10.3389/fphar.2017.00472
DO - 10.3389/fphar.2017.00472
M3 - Review article
AN - SCOPUS:85025472344
SN - 1663-9812
VL - 8
JO - Frontiers in Pharmacology
JF - Frontiers in Pharmacology
IS - JUL
M1 - 472
ER -