TY - JOUR
T1 - Central and peripheral cardiovascular, ventilatory, and motor effects of trout urotensin-II in the trout
AU - Le Mével, Jean Claude
AU - Lancien, Frédéric
AU - Mimassi, Nagi
AU - Leprince, Jérôme
AU - Conlon, J. Michael
AU - Vaudry, Hubert
N1 - Funding Information:
We thank Drs. Kenneth Olson, Daniel Conklin, David Waugh and David Smith for their help during cardiovascular in vitro and in vivo studies on trout U-II. We also would like to extend our special thanks to Dr. Mabin for his support of the research conducted throughout the years at the Faculty of Medicine in Brest where he headed the Laboratory of Neurophysiology. We are also grateful to Agnès Novella for her excellent technical assistance and care in the maintenance of the animals. This work was supported by grants from the Institut National de la Santé et de la Recherche Médicale (U650 and U413) and by the LARC-Neuroscience Network.
PY - 2008/5
Y1 - 2008/5
N2 - Urotensin-II (U-II) was originally considered to be exclusively the product of the caudal neurosecretory system (CNSS) of teleost fish, but it has now been demonstrated that U-II is widely expressed in peripheral tissues and nervous structures of species from lampreys to mammals. However, very little is known regarding the physiological effects of this peptide in its species of origin. In the present review, we summarize the most significant results relating to the cardiovascular, ventilatory, and motor effects of centrally and peripherally administered synthetic trout U-II in our experimental animal model, the unanesthetized trout Oncorhynchus mykiss. In addition, we compare the actions of U-II with those of other neurohormonal peptides, particularly with the actions of urotensin-I, a 41-amino acid residue peptide paralogous to corticotropin-releasing hormone that is co-localized with U-II within neurons of the CNSS.
AB - Urotensin-II (U-II) was originally considered to be exclusively the product of the caudal neurosecretory system (CNSS) of teleost fish, but it has now been demonstrated that U-II is widely expressed in peripheral tissues and nervous structures of species from lampreys to mammals. However, very little is known regarding the physiological effects of this peptide in its species of origin. In the present review, we summarize the most significant results relating to the cardiovascular, ventilatory, and motor effects of centrally and peripherally administered synthetic trout U-II in our experimental animal model, the unanesthetized trout Oncorhynchus mykiss. In addition, we compare the actions of U-II with those of other neurohormonal peptides, particularly with the actions of urotensin-I, a 41-amino acid residue peptide paralogous to corticotropin-releasing hormone that is co-localized with U-II within neurons of the CNSS.
KW - Blood pressure
KW - Brain
KW - Heart rate
KW - Intra-arterial injection
KW - Intracerebroventricular injection
KW - Locomotion
KW - Neuropeptides
KW - Ventilation
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U2 - 10.1016/j.peptides.2007.06.020
DO - 10.1016/j.peptides.2007.06.020
M3 - Review article
C2 - 17681644
AN - SCOPUS:42149083241
SN - 0196-9781
VL - 29
SP - 830
EP - 837
JO - Peptides
JF - Peptides
IS - 5
ER -