Cerebral MRI findings in neonatal tuberous sclerosis

Tuberous sclerosis (TS) is a developmental neuroectodermal disorder, affecting multiple organ system. Most patients are diagnosed at the age of five years or later.Only recently mutation analysis of TS Complex genes has enabed us make an early or even an entenatal diagnosis of the disease. Early onset with infantlie seizures is mainly an ominous sign for an unfavorable outcome. MRI findings in order children and adults are well-known however, only limited publications illustrate brain MRI findings in newborns. We present a female neonate with a positive family history, categorized as "definite TS." On MRI of the brain, white matter lesions were depicted. MRI findings were correlated with published data on neonatal TS.