Abstract
Competition experiments using (-)-[3H]nicotine and unlabelled nicotine revealed both high and low affinity nicotinic binding sites in temporal cortex of control and Alzheimer (AD/SDAT) brains. A significant reduction in the proportion of high affinity nicotinic binding sites (-20%) and a parallel increase in the proportion of low affinity nicotinic binding sites was obtained in AD/SDAT brain cortex compared to control brain. Moreover, a marked decrease was observed in the affinity of the low affinity nicotinic binding sites in AD/SDAT.
Original language | English |
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Pages (from-to) | 317-321 |
Number of pages | 5 |
Journal | Neuroscience Letters |
Volume | 86 |
Issue number | 3 |
DOIs | |
Publication status | Published - Apr 12 1988 |
Externally published | Yes |
Keywords
- AD/SDAT
- Alzheimer's disease
- Dementia
- Human brain
- Nicotine, [H]-
- Nicotinic receptor subtype
- Temporal cortex
ASJC Scopus subject areas
- Neuroscience(all)