Change in nicotinic receptor subtypes in temporal cortex of Alzheimer brains

Agneta Nordberg; Abdu Adem; John Hardy; Bengt Winblad

doi:10.1016/0304-3940(88)90503-4

Change in nicotinic receptor subtypes in temporal cortex of Alzheimer brains

Agneta Nordberg, Abdu Adem, John Hardy, Bengt Winblad

Research output: Contribution to journal › Article › peer-review

82 Citations (Scopus)

Abstract

Competition experiments using (-)-[³H]nicotine and unlabelled nicotine revealed both high and low affinity nicotinic binding sites in temporal cortex of control and Alzheimer (AD/SDAT) brains. A significant reduction in the proportion of high affinity nicotinic binding sites (-20%) and a parallel increase in the proportion of low affinity nicotinic binding sites was obtained in AD/SDAT brain cortex compared to control brain. Moreover, a marked decrease was observed in the affinity of the low affinity nicotinic binding sites in AD/SDAT.

Original language	English
Pages (from-to)	317-321
Number of pages	5
Journal	Neuroscience Letters
Volume	86
Issue number	3
DOIs	https://doi.org/10.1016/0304-3940(88)90503-4
Publication status	Published - Apr 12 1988
Externally published	Yes

Keywords

AD/SDAT
Alzheimer's disease
Dementia
Human brain
Nicotine, [H]-
Nicotinic receptor subtype
Temporal cortex

ASJC Scopus subject areas

Neuroscience(all)

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10.1016/0304-3940(88)90503-4

Cite this

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title = "Change in nicotinic receptor subtypes in temporal cortex of Alzheimer brains",

abstract = "Competition experiments using (-)-[3H]nicotine and unlabelled nicotine revealed both high and low affinity nicotinic binding sites in temporal cortex of control and Alzheimer (AD/SDAT) brains. A significant reduction in the proportion of high affinity nicotinic binding sites (-20%) and a parallel increase in the proportion of low affinity nicotinic binding sites was obtained in AD/SDAT brain cortex compared to control brain. Moreover, a marked decrease was observed in the affinity of the low affinity nicotinic binding sites in AD/SDAT.",

keywords = "AD/SDAT, Alzheimer's disease, Dementia, Human brain, Nicotine, [H]-, Nicotinic receptor subtype, Temporal cortex",

author = "Agneta Nordberg and Abdu Adem and John Hardy and Bengt Winblad",

note = "Funding Information: This study was supported by grants from the Swedish Medical Research Council, The Swedish Tobacco Company, Stiftelsen ffr Gamla Tjfinarinnor. The technical assistance of Mrs. Barbro Synnergren is highly appreciated.",

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T1 - Change in nicotinic receptor subtypes in temporal cortex of Alzheimer brains

AU - Nordberg, Agneta

AU - Adem, Abdu

AU - Hardy, John

AU - Winblad, Bengt

N1 - Funding Information: This study was supported by grants from the Swedish Medical Research Council, The Swedish Tobacco Company, Stiftelsen ffr Gamla Tjfinarinnor. The technical assistance of Mrs. Barbro Synnergren is highly appreciated.

PY - 1988/4/12

Y1 - 1988/4/12

N2 - Competition experiments using (-)-[3H]nicotine and unlabelled nicotine revealed both high and low affinity nicotinic binding sites in temporal cortex of control and Alzheimer (AD/SDAT) brains. A significant reduction in the proportion of high affinity nicotinic binding sites (-20%) and a parallel increase in the proportion of low affinity nicotinic binding sites was obtained in AD/SDAT brain cortex compared to control brain. Moreover, a marked decrease was observed in the affinity of the low affinity nicotinic binding sites in AD/SDAT.

AB - Competition experiments using (-)-[3H]nicotine and unlabelled nicotine revealed both high and low affinity nicotinic binding sites in temporal cortex of control and Alzheimer (AD/SDAT) brains. A significant reduction in the proportion of high affinity nicotinic binding sites (-20%) and a parallel increase in the proportion of low affinity nicotinic binding sites was obtained in AD/SDAT brain cortex compared to control brain. Moreover, a marked decrease was observed in the affinity of the low affinity nicotinic binding sites in AD/SDAT.

KW - AD/SDAT

KW - Alzheimer's disease

KW - Dementia

KW - Human brain

KW - Nicotine, [H]-

KW - Nicotinic receptor subtype

KW - Temporal cortex

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JO - Neuroscience Letters

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Change in nicotinic receptor subtypes in temporal cortex of Alzheimer brains

Abstract

Keywords

ASJC Scopus subject areas

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