TY - JOUR
T1 - Changes in human regional cerebral blood flow following hypertonic saline induced experimental muscle pain
T2 - A positron emission tomography study
AU - Korotkov, Alexander
AU - Ljubisavljevic, Milos
AU - Thunberg, Johan
AU - Kataeva, Galina
AU - Roudas, Marina
AU - Pakhomov, Sergey
AU - Radovanovic, Sasa
AU - Lyskov, Eugene
AU - Medvedev, Sviatoslav
AU - Johansson, Håkan
N1 - Funding Information:
This study was supported by grants from the Swedish Council for Work Life Research, Inga-Britt and Arne Lundbergs Forskningsstiftelse and from Russian Foundation for the Humanities No. 02-06-00063a. We are grateful to Prof. U. Windhorst for comments on the manuscript.
PY - 2002/12/25
Y1 - 2002/12/25
N2 - A positron emission tomography imaging study was performed on 16 healthy volunteers to reveal changes in cortical activation during acute muscle pain induced by intra-muscular injection of hypertonic saline into the left triceps brachii muscle. Changes in regional cerebral blood flow (rCBF) were measured with the use of [15O] labelled water during 'Rest1', 'Needle' (insertion of a needle without injection), 'Rest2' and 'Pain' conditions. Differences in rCBF were found in the comparison of Pain and Needle, and Pain and Rest2 conditions, revealing activation of the contralateral insula and putamen. The results are discussed with respect to possible differences in brain processing of muscle and cutaneous noxious inputs.
AB - A positron emission tomography imaging study was performed on 16 healthy volunteers to reveal changes in cortical activation during acute muscle pain induced by intra-muscular injection of hypertonic saline into the left triceps brachii muscle. Changes in regional cerebral blood flow (rCBF) were measured with the use of [15O] labelled water during 'Rest1', 'Needle' (insertion of a needle without injection), 'Rest2' and 'Pain' conditions. Differences in rCBF were found in the comparison of Pain and Needle, and Pain and Rest2 conditions, revealing activation of the contralateral insula and putamen. The results are discussed with respect to possible differences in brain processing of muscle and cutaneous noxious inputs.
KW - Central pain mechanisms
KW - Hypertonic Saline
KW - Imaging
KW - Muscle Pain
KW - Positron emission tomography
KW - Regional cerebral blood flow
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U2 - 10.1016/S0304-3940(02)01181-3
DO - 10.1016/S0304-3940(02)01181-3
M3 - Article
C2 - 12459513
AN - SCOPUS:0037176189
SN - 0304-3940
VL - 335
SP - 119
EP - 123
JO - Neuroscience Letters
JF - Neuroscience Letters
IS - 2
ER -