Changes in IGF-1 receptors in the hippocampus of adult rats after long- term adrenalectomy: Receptor autoradiography and in situ hybridization histochemistry

A. Islam; C. Ayer-Lelievre; C. Heigensköld; N. Bogdanovic; B. Winblad; A. Adem

doi:10.1016/S0006-8993(98)00389-8

Changes in IGF-1 receptors in the hippocampus of adult rats after long- term adrenalectomy: Receptor autoradiography and in situ hybridization histochemistry

A. Islam
, C. Ayer-Lelievre
, C. Heigensköld
, N. Bogdanovic
, B. Winblad
, A. Adem

Research output: Contribution to journal › Article › peer-review

16 Citations (Scopus)

Abstract

Alteration of insulin-like growth factor-1 (IGF-1) receptor and its mRNA after long-term adrenalectomy (ADX) was studied in the hippocampus by in vitro receptor autoradiography and in situ hybridization histochemistry, respectively. Significantly, decreased levels of IGF-1 receptor and its mRNA was noted in the dentate and CA1-CA4 regions of the hippocampus of the ADX animals, suggesting that the level and expression of IGF-1 receptors in the hippocampus is influenced by adrenal hormones.

Original language	English
Pages (from-to)	342-346
Number of pages	5
Journal	Brain Research
Volume	797
Issue number	2
DOIs	https://doi.org/10.1016/S0006-8993(98)00389-8
Publication status	Published - Jun 29 1998
Externally published	Yes

Keywords

Apoptosis
Corticosteroid
Growth factor
Neurodegeneration

ASJC Scopus subject areas

General Neuroscience
Molecular Biology
Clinical Neurology
Developmental Biology

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10.1016/S0006-8993(98)00389-8

Cite this

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title = "Changes in IGF-1 receptors in the hippocampus of adult rats after long- term adrenalectomy: Receptor autoradiography and in situ hybridization histochemistry",

abstract = "Alteration of insulin-like growth factor-1 (IGF-1) receptor and its mRNA after long-term adrenalectomy (ADX) was studied in the hippocampus by in vitro receptor autoradiography and in situ hybridization histochemistry, respectively. Significantly, decreased levels of IGF-1 receptor and its mRNA was noted in the dentate and CA1-CA4 regions of the hippocampus of the ADX animals, suggesting that the level and expression of IGF-1 receptors in the hippocampus is influenced by adrenal hormones.",

keywords = "Apoptosis, Corticosteroid, Growth factor, Neurodegeneration",

author = "A. Islam and C. Ayer-Lelievre and C. Heigensk{\"o}ld and N. Bogdanovic and B. Winblad and A. Adem",

note = "Funding Information: This study was supported by grants Loo och Hans Ostermans Fund, Swedish Society for Medical Research, Stiftelsen Sigurd och Elsa Goljes Minne, KI fonder, Greta Lindenau Hansells Minnesfond and Gamla Tj{\"a}narinnor Foundation. -IGF-1 was donated by Prof. V. Sara. Technical assistance of Ingvild Halbig and Dr. Adlan ElHassan is gratefully acknowledged.",

year = "1998",

month = jun,

day = "29",

doi = "10.1016/S0006-8993(98)00389-8",

language = "English",

volume = "797",

pages = "342--346",

journal = "Brain Research",

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number = "2",

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TY - JOUR

T1 - Changes in IGF-1 receptors in the hippocampus of adult rats after long- term adrenalectomy

T2 - Receptor autoradiography and in situ hybridization histochemistry

AU - Islam, A.

AU - Ayer-Lelievre, C.

AU - Heigensköld, C.

AU - Bogdanovic, N.

AU - Winblad, B.

AU - Adem, A.

N1 - Funding Information: This study was supported by grants Loo och Hans Ostermans Fund, Swedish Society for Medical Research, Stiftelsen Sigurd och Elsa Goljes Minne, KI fonder, Greta Lindenau Hansells Minnesfond and Gamla Tjänarinnor Foundation. -IGF-1 was donated by Prof. V. Sara. Technical assistance of Ingvild Halbig and Dr. Adlan ElHassan is gratefully acknowledged.

PY - 1998/6/29

Y1 - 1998/6/29

N2 - Alteration of insulin-like growth factor-1 (IGF-1) receptor and its mRNA after long-term adrenalectomy (ADX) was studied in the hippocampus by in vitro receptor autoradiography and in situ hybridization histochemistry, respectively. Significantly, decreased levels of IGF-1 receptor and its mRNA was noted in the dentate and CA1-CA4 regions of the hippocampus of the ADX animals, suggesting that the level and expression of IGF-1 receptors in the hippocampus is influenced by adrenal hormones.

AB - Alteration of insulin-like growth factor-1 (IGF-1) receptor and its mRNA after long-term adrenalectomy (ADX) was studied in the hippocampus by in vitro receptor autoradiography and in situ hybridization histochemistry, respectively. Significantly, decreased levels of IGF-1 receptor and its mRNA was noted in the dentate and CA1-CA4 regions of the hippocampus of the ADX animals, suggesting that the level and expression of IGF-1 receptors in the hippocampus is influenced by adrenal hormones.

KW - Apoptosis

KW - Corticosteroid

KW - Growth factor

KW - Neurodegeneration

UR - https://www.scopus.com/pages/publications/0032577999

UR - https://www.scopus.com/pages/publications/0032577999#tab=citedBy

U2 - 10.1016/S0006-8993(98)00389-8

DO - 10.1016/S0006-8993(98)00389-8

M3 - Article

C2 - 9666167

AN - SCOPUS:0032577999

SN - 0006-8993

VL - 797

SP - 342

EP - 346

JO - Brain Research

JF - Brain Research

IS - 2

ER -

Changes in IGF-1 receptors in the hippocampus of adult rats after long- term adrenalectomy: Receptor autoradiography and in situ hybridization histochemistry

Abstract

Keywords

ASJC Scopus subject areas

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