TY - JOUR
T1 - Changes in QTc interval after hydroxychloroquine therapy in patients with COVID-19 infection
T2 - A large, retrospective, multicentre cohort study
AU - El Kadri, Moutaz
AU - Al Falasi, Omar
AU - Ahmed, Rizwan
AU - Al Awadhi, Ahlam
AU - Altaha, Zainab
AU - Hillis, Amany
AU - Panikkaveetil, Basheer
AU - Abdalla, Sara
AU - Ansel Benette, Honey
AU - Almubarak, Adhba
AU - Saifuddin, Mohammed
AU - Alattar, Yousef
AU - Oulhaj, Abderrahim
AU - Alkaabi, Salem
N1 - Publisher Copyright:
© 2022 Author(s). Published by BMJ.
PY - 2022/2/9
Y1 - 2022/2/9
N2 - Objective To evaluate the extent of hydroxychloroquine-induced corrected QT (QTc) prolongation and its relation to COVID-19 infection severity and incidence of polymorphic ventricular arrhythmias and sudden arrhythmic deaths. Design A large-scale cohort study with retrospective analysis of baseline and on-therapy QT interval corrected using Bazett and Fridericia formulas. Setting A multicentre study involving eight secondary and tertiary care hospitals of the Abu Dhabi Health Services Company (SEHA), United Arab Emirates. Participants 2014 patients consecutively admitted with PCR-confirmed SARS-CoV-2 infection between 1 March 2020 and 1 June 2020. Interventions Treatment with hydroxychloroquine alone or in combination with azithromycin for at least 24 hours and with a baseline ECG and at least one ECG after 24 hours of therapy. Main outcome measures Maximal QTc interval prolongation and its relationship to clinical severity, polymorphic ventricular tachycardia and sudden arrhythmic death while on treatment. Results The baseline QTc (Bazett) was 427.6±25.4 ms and the maximum QTc (Bazett) during treatment was 439.2±30.4 ms (p<0.001). Severe QTc prolongation (QTc ≥500 ms) was observed in 1.7%-3.3% of patients (Fridericia and Bazett, respectively). There were no cases of polymorphic ventricular arrhythmia or hydroxychloroquine-related arrhythmic death. QTc prolongation was more pronounced in combination therapy compared with hydroxychloroquine alone (22.2 ms vs 11.0 ms, p<0.001) and in patients with higher COVID-19 clinical severity (asymptomatic: 428.4±25.4 ms, severe COVID-19 infection: 452.7±35.7 ms, p<0.001). The overall in-hospital mortality was 3.97% and deceased patients had longer on-therapy QTc (Bazett) than survivors (459.8±21.4 ms vs 438.4±29.9 ms, p<0.001). Conclusions The incidence of severe QTc prolongation with hydroxychloroquine was low and not associated with ventricular arrhythmia. The safety concerns surrounding the use of hydroxychloroquine may have been overestimated; however, caution should be exercised when using hydroxychloroquine in patients with risk factors for QT prolongation.
AB - Objective To evaluate the extent of hydroxychloroquine-induced corrected QT (QTc) prolongation and its relation to COVID-19 infection severity and incidence of polymorphic ventricular arrhythmias and sudden arrhythmic deaths. Design A large-scale cohort study with retrospective analysis of baseline and on-therapy QT interval corrected using Bazett and Fridericia formulas. Setting A multicentre study involving eight secondary and tertiary care hospitals of the Abu Dhabi Health Services Company (SEHA), United Arab Emirates. Participants 2014 patients consecutively admitted with PCR-confirmed SARS-CoV-2 infection between 1 March 2020 and 1 June 2020. Interventions Treatment with hydroxychloroquine alone or in combination with azithromycin for at least 24 hours and with a baseline ECG and at least one ECG after 24 hours of therapy. Main outcome measures Maximal QTc interval prolongation and its relationship to clinical severity, polymorphic ventricular tachycardia and sudden arrhythmic death while on treatment. Results The baseline QTc (Bazett) was 427.6±25.4 ms and the maximum QTc (Bazett) during treatment was 439.2±30.4 ms (p<0.001). Severe QTc prolongation (QTc ≥500 ms) was observed in 1.7%-3.3% of patients (Fridericia and Bazett, respectively). There were no cases of polymorphic ventricular arrhythmia or hydroxychloroquine-related arrhythmic death. QTc prolongation was more pronounced in combination therapy compared with hydroxychloroquine alone (22.2 ms vs 11.0 ms, p<0.001) and in patients with higher COVID-19 clinical severity (asymptomatic: 428.4±25.4 ms, severe COVID-19 infection: 452.7±35.7 ms, p<0.001). The overall in-hospital mortality was 3.97% and deceased patients had longer on-therapy QTc (Bazett) than survivors (459.8±21.4 ms vs 438.4±29.9 ms, p<0.001). Conclusions The incidence of severe QTc prolongation with hydroxychloroquine was low and not associated with ventricular arrhythmia. The safety concerns surrounding the use of hydroxychloroquine may have been overestimated; however, caution should be exercised when using hydroxychloroquine in patients with risk factors for QT prolongation.
KW - COVID-19
KW - adult cardiology
KW - clinical pharmacology
UR - http://www.scopus.com/inward/record.url?scp=85124252081&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85124252081&partnerID=8YFLogxK
U2 - 10.1136/bmjopen-2021-051579
DO - 10.1136/bmjopen-2021-051579
M3 - Article
C2 - 35140148
AN - SCOPUS:85124252081
SN - 2044-6055
VL - 12
JO - BMJ Open
JF - BMJ Open
IS - 2
M1 - e051579
ER -