TY - JOUR
T1 - Changes in the neuropsychological correlates of clinical dimensions between the acute and stable phase of schizophrenia
AU - Guillem, François
AU - Ganeva, Emilia
AU - Pampoulova, Tania
AU - Stip, Emmanuel
AU - Lalonde, Pierre
AU - Sasseville, Marc
N1 - Funding Information:
This research was supported by the Canadian Institutes of Health Research (CIHR-MOP49530). We are particularly grateful to the personnel of the in- and outpatient clinics associated to the L-H Lafontaine for helpful assistance in patient’s approach and recruitment and evaluations.
PY - 2005/2
Y1 - 2005/2
N2 - This study was designed to investigate whether the neuropsychological correlates of the symptom dimensions of schizophrenia vary with the clinical state in patients followed from the acute to stable the phase of the illness. Fifteen patients were assessed for symptoms (SAPS-SANS) and undergone a complete neuropsychological assessment at two sessions. The first session (S1) was carried out within six days after admission, i.e., acute phase and the second (S2) at least two month after hospitalization, i.e., stable phase. The data were analyzed using stepwise regression models in which neuropsychological scores were in entered to predict each dimensional score. This analysis was applied on the S1 and S2 data as well as on the S2 - S1 difference to assess the neuropsychological predictors of clinical changes. Generally, the results replicate the previous associations between neuropsychological and dimensional measures found in stable patients. In addition, this study shows if each dimension appears to rely on a key structure, symptom variations seems to involve changes in the spread of the dysfunction and/or changes in the connectivity between the key and other regions. The results also suggest that functional changes related to some symptoms dimensions occur to compensate for the dysfunction associated with other symptoms.
AB - This study was designed to investigate whether the neuropsychological correlates of the symptom dimensions of schizophrenia vary with the clinical state in patients followed from the acute to stable the phase of the illness. Fifteen patients were assessed for symptoms (SAPS-SANS) and undergone a complete neuropsychological assessment at two sessions. The first session (S1) was carried out within six days after admission, i.e., acute phase and the second (S2) at least two month after hospitalization, i.e., stable phase. The data were analyzed using stepwise regression models in which neuropsychological scores were in entered to predict each dimensional score. This analysis was applied on the S1 and S2 data as well as on the S2 - S1 difference to assess the neuropsychological predictors of clinical changes. Generally, the results replicate the previous associations between neuropsychological and dimensional measures found in stable patients. In addition, this study shows if each dimension appears to rely on a key structure, symptom variations seems to involve changes in the spread of the dysfunction and/or changes in the connectivity between the key and other regions. The results also suggest that functional changes related to some symptoms dimensions occur to compensate for the dysfunction associated with other symptoms.
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U2 - 10.1016/j.bandc.2004.08.027
DO - 10.1016/j.bandc.2004.08.027
M3 - Article
C2 - 15629220
AN - SCOPUS:11144274433
SN - 0278-2626
VL - 57
SP - 93
EP - 101
JO - Brain and Cognition
JF - Brain and Cognition
IS - 1
ER -