Changing socioeconomic risk factors for invasive H. influenzae disease after the introduction of conjugate vaccine

Babatunde Olowokure, N. J. Spencer, J. I. Hawker, I. Blair, R. L. Smith

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

Objectives: To determine socioeconomic risk factors for invasive Haemophilus influenzae (HI) disease before and after the introduction of HI type b (Hib) conjugate vaccine in the West Midlands, UK. Methods: Study population consisted of children aged <5 years with laboratory confirmed invasive disease. Linear associations between disease rates and socioeconomic variables were examined 2-years before and 2-years after the introduction of conjugate vaccine. Results: Pre-vaccine there were no trends in disease incidence. Post-vaccine there was an absolute reduction in disease incidence and significant disease differentials between affluent and deprived populations were identified for non-owner-occupancy (P = 0.032) and car access (P = 0.049). Conclusions: Our results suggest that changes in socioeconomic risk factor for invasive HI occurred after the introduction of conjugate vaccine. This may have implications for future immunisation strategies.

Original languageEnglish
Pages (from-to)46-48
Number of pages3
JournalJournal of Infection
Volume46
Issue number1
DOIs
Publication statusPublished - Jan 2003

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

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