TY - JOUR
T1 - Changing socioeconomic risk factors for invasive H. influenzae disease after the introduction of conjugate vaccine
AU - Olowokure, Babatunde
AU - Spencer, N. J.
AU - Hawker, J. I.
AU - Blair, I.
AU - Smith, R. L.
N1 - Funding Information:
We are grateful to the Public Health Laboratory Service Communicable Disease Surveillance Centre, and all the consultant microbiologists, consultants in communicable disease control, immunisation co-ordinators, consultant paediatricians, and the medical records managers who contributed to this study by providing access to information on their patients. We are also grateful to the Oxford Vaccine Group and the British Paediatric Surveillance Unit for providing information on cases reported to them as part of the study of Hib conjugate vaccine failures. We thank Dr John Weil, Dr Rob Stevens and Mr Tim Marshall for reviewing earlier drafts. This study was funded by a grant from the Charities of the City of Coventry and partly funded by the Warwickshire Child Health Group.
PY - 2003/1
Y1 - 2003/1
N2 - Objectives: To determine socioeconomic risk factors for invasive Haemophilus influenzae (HI) disease before and after the introduction of HI type b (Hib) conjugate vaccine in the West Midlands, UK. Methods: Study population consisted of children aged <5 years with laboratory confirmed invasive disease. Linear associations between disease rates and socioeconomic variables were examined 2-years before and 2-years after the introduction of conjugate vaccine. Results: Pre-vaccine there were no trends in disease incidence. Post-vaccine there was an absolute reduction in disease incidence and significant disease differentials between affluent and deprived populations were identified for non-owner-occupancy (P = 0.032) and car access (P = 0.049). Conclusions: Our results suggest that changes in socioeconomic risk factor for invasive HI occurred after the introduction of conjugate vaccine. This may have implications for future immunisation strategies.
AB - Objectives: To determine socioeconomic risk factors for invasive Haemophilus influenzae (HI) disease before and after the introduction of HI type b (Hib) conjugate vaccine in the West Midlands, UK. Methods: Study population consisted of children aged <5 years with laboratory confirmed invasive disease. Linear associations between disease rates and socioeconomic variables were examined 2-years before and 2-years after the introduction of conjugate vaccine. Results: Pre-vaccine there were no trends in disease incidence. Post-vaccine there was an absolute reduction in disease incidence and significant disease differentials between affluent and deprived populations were identified for non-owner-occupancy (P = 0.032) and car access (P = 0.049). Conclusions: Our results suggest that changes in socioeconomic risk factor for invasive HI occurred after the introduction of conjugate vaccine. This may have implications for future immunisation strategies.
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U2 - 10.1053/jinf.2002.1069
DO - 10.1053/jinf.2002.1069
M3 - Article
C2 - 12504608
AN - SCOPUS:0142123573
SN - 0163-4453
VL - 46
SP - 46
EP - 48
JO - Journal of Infection
JF - Journal of Infection
IS - 1
ER -