TY - CHAP
T1 - CHAPTER 9
T2 - Gold-nanoparticles Interface-based Electrochemical Immunosensors for Tumor Biomarkers
AU - Halawa, Mohamed Ibrahim
AU - Lou, Baohua
AU - Xu, Guobao
N1 - Publisher Copyright:
© The Royal Society of Chemistry 2019.
PY - 2019
Y1 - 2019
N2 - The implementation of gold nanoparticles (AuNPs) in electrochemical immunoassays of cancer biomarkers has been in place for several years. AuNPs play crucial roles in the development of a convenient interface for the immobilization of antibodies, facilitating the electron transfer process through a developed interface and signal amplification by several orders of magnitude. Additionally, because of the unique properties of AuNPs, AuNPs-based electrochemical immunosensors offer ultrasensitive, biocompatible, rapid and inexpensive sensing approaches with the feasibility of on-line monitoring and simultaneous sensing of multiple cancer biomarkers. Herein, we summarize different synthetic strategies of AuNPs and their main roles in the design of electrochemical immunosensors. Moreover, the different applications of AuNPs in developing electrochemical immunosensors for very common tumor biomarkers such as PSA, CEA, AFP, CA125 and hCG are briefly discussed in this chapter.
AB - The implementation of gold nanoparticles (AuNPs) in electrochemical immunoassays of cancer biomarkers has been in place for several years. AuNPs play crucial roles in the development of a convenient interface for the immobilization of antibodies, facilitating the electron transfer process through a developed interface and signal amplification by several orders of magnitude. Additionally, because of the unique properties of AuNPs, AuNPs-based electrochemical immunosensors offer ultrasensitive, biocompatible, rapid and inexpensive sensing approaches with the feasibility of on-line monitoring and simultaneous sensing of multiple cancer biomarkers. Herein, we summarize different synthetic strategies of AuNPs and their main roles in the design of electrochemical immunosensors. Moreover, the different applications of AuNPs in developing electrochemical immunosensors for very common tumor biomarkers such as PSA, CEA, AFP, CA125 and hCG are briefly discussed in this chapter.
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U2 - 10.1039/9781788016162-00186
DO - 10.1039/9781788016162-00186
M3 - Chapter
AN - SCOPUS:85072265006
T3 - RSC Detection Science
SP - 186
EP - 218
BT - Carbon-based Nanomaterials in Analytical Chemistry
A2 - Ahmed, Minhaz Uddin
A2 - Zourob, Mohammed
A2 - Tamiya, Eiichi
PB - Royal Society of Chemistry
ER -
