CHAPTER 9: Gold-nanoparticles Interface-based Electrochemical Immunosensors for Tumor Biomarkers

Mohamed Ibrahim Halawa; Baohua Lou; Guobao Xu

doi:10.1039/9781788016162-00186

CHAPTER 9: Gold-nanoparticles Interface-based Electrochemical Immunosensors for Tumor Biomarkers

Mohamed Ibrahim Halawa
, Baohua Lou
, Guobao Xu

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

The implementation of gold nanoparticles (AuNPs) in electrochemical immunoassays of cancer biomarkers has been in place for several years. AuNPs play crucial roles in the development of a convenient interface for the immobilization of antibodies, facilitating the electron transfer process through a developed interface and signal amplification by several orders of magnitude. Additionally, because of the unique properties of AuNPs, AuNPs-based electrochemical immunosensors offer ultrasensitive, biocompatible, rapid and inexpensive sensing approaches with the feasibility of on-line monitoring and simultaneous sensing of multiple cancer biomarkers. Herein, we summarize different synthetic strategies of AuNPs and their main roles in the design of electrochemical immunosensors. Moreover, the different applications of AuNPs in developing electrochemical immunosensors for very common tumor biomarkers such as PSA, CEA, AFP, CA125 and hCG are briefly discussed in this chapter.

Original language	English
Title of host publication	Carbon-based Nanomaterials in Analytical Chemistry
Editors	Minhaz Uddin Ahmed, Mohammed Zourob, Eiichi Tamiya
Publisher	Royal Society of Chemistry
Pages	186-218
Number of pages	33
Edition	14
ISBN (Electronic)	9781788011020, 9781788014373
DOIs	https://doi.org/10.1039/9781788016162-00186
Publication status	Published - 2019
Externally published	Yes

Publication series

Name	RSC Detection Science
Number	14
Volume	2019-January
ISSN (Print)	2052-3068
ISSN (Electronic)	2052-3076

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

ASJC Scopus subject areas

Bioengineering
Pathology and Forensic Medicine
General Chemistry
Environmental Chemistry
General Biochemistry,Genetics and Molecular Biology
Pollution
Biochemistry, medical

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10.1039/9781788016162-00186

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Halawa, M. I., Lou, B., & Xu, G. (2019). CHAPTER 9: Gold-nanoparticles Interface-based Electrochemical Immunosensors for Tumor Biomarkers. In M. U. Ahmed, M. Zourob, & E. Tamiya (Eds.), Carbon-based Nanomaterials in Analytical Chemistry (14 ed., pp. 186-218). (RSC Detection Science; Vol. 2019-January, No. 14). Royal Society of Chemistry. https://doi.org/10.1039/9781788016162-00186

CHAPTER 9: Gold-nanoparticles Interface-based Electrochemical Immunosensors for Tumor Biomarkers. / Halawa, Mohamed Ibrahim; Lou, Baohua; Xu, Guobao.
Carbon-based Nanomaterials in Analytical Chemistry. ed. / Minhaz Uddin Ahmed; Mohammed Zourob; Eiichi Tamiya. 14. ed. Royal Society of Chemistry, 2019. p. 186-218 (RSC Detection Science; Vol. 2019-January, No. 14).

Research output: Chapter in Book/Report/Conference proceeding › Chapter

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CHAPTER 9: Gold-nanoparticles Interface-based Electrochemical Immunosensors for Tumor Biomarkers

Abstract

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