Characterization and identification of novel antidiabetic and anti-obesity peptides from camel milk protein hydrolysates

Priti Mudgil, Hina Kamal, Gan Chee Yuen, Sajid Maqsood

    Research output: Contribution to journalArticlepeer-review

    173 Citations (Scopus)

    Abstract

    In-vitro inhibitory properties of peptides released from camel milk proteins against dipeptidyl peptidase-IV (DPP-IV), porcine pancreatic α-amylase (PPA), and porcine pancreatic lipase (PPL) were studied. Results revealed that upon hydrolysis by different enzymes, camel milk proteins displayed dramatic increase in inhibition of DPP-IV and PPL, but slight improvement in PPA inhibition was noticed. Peptide sequencing revealed a total of 20 and 3 peptides for A9 and B9 hydrolysates respectively, obtained the score of 0.8 or more on peptide ranker and were categorized as potential DPP-IV inhibitory peptides. KDLWDDFKGL in A9 and MPSKPPLL in B9 were identified as most potent PPA inhibitory peptide. For PPL inhibition only 7 and 2 peptides qualified as PPL inhibitory peptides from hydrolysates A9 and B9, respectively. The present study report for the first time PPA and PPL inhibitory and only second for DPP-IV inhibitory potential of protein hydrolysates from camel milk.

    Original languageEnglish
    Pages (from-to)46-54
    Number of pages9
    JournalFood Chemistry
    Volume259
    DOIs
    Publication statusPublished - Sept 1 2018

    Keywords

    • Alcalase
    • Bioactive peptides
    • Bromelain
    • Camel milk proteins
    • Dipeptidyl peptidase IV inhibition
    • Pancreatic lipase inhibition
    • Pancreatic α-amylase inhibition
    • Papain

    ASJC Scopus subject areas

    • Analytical Chemistry
    • Food Science

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