Characterization of an amidated form of pancreatic polypeptide from the daddy sculpin (Cottus scorpius)

J. M. Conlon, W. E. Schmidt, B. Gallwitz, S. Falkmer, L. Thim

Research output: Contribution to journalArticlepeer-review

39 Citations (Scopus)


The primary structure of pancreatic polypeptide from the teleostean fish, Cottus scorpius (daddy sculpin) was established as: Y P P Q P E S P G G N A S P E D W A K Y H A A V R H Y V N L I T R Q R Y NH2. The presence of a COOH-terminally α-amidated amino acid was established using an HPLC method of general applicability. Although the peptide shows strong homology towards anglerfish pancreatic polypeptide (86%), homology towards porcine peptide YY (PYY) (61%) and porcine neuropeptide Y (NPY) (61%) was greater than towards porcine pancreatic polypeptide (PP) (47%). This result supports suggestions that the gene duplication events which led to PP, NPY and PYY formation took place after the time of divergence of fish and mammals.

Original languageEnglish
Pages (from-to)261-268
Number of pages8
JournalRegulatory Peptides
Issue number3-4
Publication statusPublished - Dec 30 1986
Externally publishedYes


  • HPLC
  • primary structure
  • teleost pancreatic islet

ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Endocrinology
  • Clinical Biochemistry
  • Cellular and Molecular Neuroscience


Dive into the research topics of 'Characterization of an amidated form of pancreatic polypeptide from the daddy sculpin (Cottus scorpius)'. Together they form a unique fingerprint.

Cite this