Chemically formed HAp-Ca poly(vinyl phosphonate) composites

Y. E. Greish; P. W. Brown

doi:10.1016/S0142-9612(00)00243-X

Chemically formed HAp-Ca poly(vinyl phosphonate) composites

Y. E. Greish, P. W. Brown

Research output: Contribution to journal › Article › peer-review

63 Citations (Scopus)

Abstract

The formation of biocompatible organic-inorganic composites by reactions between tetracalcium phosphate (Ca₄(PO₄)₂O, TetCP) and the biomedical polymer poly(vinyl phosphonic acid) (PVPA) is described. Composites were prepared by hot pressing mixtures of these powders at 80kpsi and 300°C for 30min. Composite formation was investigated depending on the proportions of reactants and the processing route used. Two inorganic phases were produced as a result of the acid-base reaction between TetCP and PVPA: hydroxyapatite (Ca₁₀(PO₄)₆(OH)₂, HAp) and anhydrous dicalcium phosphate (CaHPO₄, DCPA). The later phase preferentially formed at lower TetCP/PVPA ratios while the amount of HAp increased with increasing TetCP/PVPA ratio. The reactions appear to start with the softening of the polymer when heated to T>T_g. The flowing polymer surrounds the TetCP grains permitting the TetCP to initially form DCPA crystallites in a matrix of the Ca salt of the polymer. When H₂O is added prior to pressing, the DCPA produced reacts with the remaining TetCP forming HAp.

Original language	English
Pages (from-to)	807-816
Number of pages	10
Journal	Biomaterials
Volume	22
Issue number	8
DOIs	https://doi.org/10.1016/S0142-9612(00)00243-X
Publication status	Published - 2001
Externally published	Yes

Keywords

Biomaterials
Hot pressing
Hydroxyapatite
Poly(vinyl phosphonic acid)
Tetracalcium phosphate

ASJC Scopus subject areas

Bioengineering
Ceramics and Composites
Biophysics
Biomaterials
Mechanics of Materials

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10.1016/S0142-9612(00)00243-X

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title = "Chemically formed HAp-Ca poly(vinyl phosphonate) composites",

abstract = "The formation of biocompatible organic-inorganic composites by reactions between tetracalcium phosphate (Ca4(PO4)2O, TetCP) and the biomedical polymer poly(vinyl phosphonic acid) (PVPA) is described. Composites were prepared by hot pressing mixtures of these powders at 80kpsi and 300°C for 30min. Composite formation was investigated depending on the proportions of reactants and the processing route used. Two inorganic phases were produced as a result of the acid-base reaction between TetCP and PVPA: hydroxyapatite (Ca10(PO4)6(OH)2, HAp) and anhydrous dicalcium phosphate (CaHPO4, DCPA). The later phase preferentially formed at lower TetCP/PVPA ratios while the amount of HAp increased with increasing TetCP/PVPA ratio. The reactions appear to start with the softening of the polymer when heated to T>Tg. The flowing polymer surrounds the TetCP grains permitting the TetCP to initially form DCPA crystallites in a matrix of the Ca salt of the polymer. When H2O is added prior to pressing, the DCPA produced reacts with the remaining TetCP forming HAp.",

keywords = "Biomaterials, Hot pressing, Hydroxyapatite, Poly(vinyl phosphonic acid), Tetracalcium phosphate",

author = "Greish, {Y. E.} and Brown, {P. W.}",

year = "2001",

doi = "10.1016/S0142-9612(00)00243-X",

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AU - Greish, Y. E.

AU - Brown, P. W.

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AB - The formation of biocompatible organic-inorganic composites by reactions between tetracalcium phosphate (Ca4(PO4)2O, TetCP) and the biomedical polymer poly(vinyl phosphonic acid) (PVPA) is described. Composites were prepared by hot pressing mixtures of these powders at 80kpsi and 300°C for 30min. Composite formation was investigated depending on the proportions of reactants and the processing route used. Two inorganic phases were produced as a result of the acid-base reaction between TetCP and PVPA: hydroxyapatite (Ca10(PO4)6(OH)2, HAp) and anhydrous dicalcium phosphate (CaHPO4, DCPA). The later phase preferentially formed at lower TetCP/PVPA ratios while the amount of HAp increased with increasing TetCP/PVPA ratio. The reactions appear to start with the softening of the polymer when heated to T>Tg. The flowing polymer surrounds the TetCP grains permitting the TetCP to initially form DCPA crystallites in a matrix of the Ca salt of the polymer. When H2O is added prior to pressing, the DCPA produced reacts with the remaining TetCP forming HAp.

KW - Biomaterials

KW - Hot pressing

KW - Hydroxyapatite

KW - Poly(vinyl phosphonic acid)

KW - Tetracalcium phosphate

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ER -

Chemically formed HAp-Ca poly(vinyl phosphonate) composites

Abstract

Keywords

ASJC Scopus subject areas

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