Chemopreventive activities of Trigonella foenum graecum (Fenugreek) against breast cancer

Amr Amin, Aysha Alkaabi, Shamaa Al-Falasi, Sayel A. Daoud

Research output: Contribution to journalArticlepeer-review

156 Citations (Scopus)

Abstract

Cancer is the second leading cause of death worldwide. Conventional therapies cause serious side effects and, at best, merely extend the patient's lifespan by a few years. Cancer control may therefore benefit from the potential that resides in alternative therapies. There is thus an increasing demand to utilize alternative concepts or approaches to the prevention of cancer. In this report, we show a potential protective effect of Fenugreek seeds against 7,12-dimethylbenz(α)anthracene (DMBA)-induced breast cancer in rats. At 200 mg/kg b.wt., Fenugreek seeds' extract significantly inhibited the DMBA-induced mammary hyperplasia and decreased its incidence. Epidemiological studies also implicate apoptosis as a mechanism that might mediate the Fenugreek's anti-breast cancer protective effects. To our knowledge, this is the first study that suggests significant chemopreventive effects of Fenugreek seeds against breast cancer.

Original languageEnglish
Pages (from-to)687-694
Number of pages8
JournalCell Biology International
Volume29
Issue number8
DOIs
Publication statusPublished - Aug 2005

Keywords

  • Breast cancer
  • Chemoprevention
  • Fenugreek
  • Rat

ASJC Scopus subject areas

  • Cell Biology

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