Chitosan functionalized Mn3O4 nanoparticles counteracts ulcerative colitis in mice through modulation of cellular redox state

Susmita Mondal, Monojit Das, Ria Ghosh, Manali Singh, Aniruddha Adhikari, Soumendra Darbar, Anjan Kumar Das, Siddhartha Sankar Bhattacharya, Debasish Pal, Debasish Bhattacharyya, Ahmed S.A. Ahmed, Asim Kumar Mallick, Munirah M. Al-Rooqi, Ziad Moussa, Saleh A. Ahmed, Samir Kumar Pal

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

Recent findings suggest a key role for reactive oxygen species (ROS) in the pathogenesis and progression of ulcerative colitis (UC). Several studies have also highlighted the efficacy of citrate functionalized Mn3O4 nanoparticles as redox medicine against a number of ROS-mediated disorders. Here we show that synthesized nanoparticles consisting of chitosan functionalized tri-manganese tetroxide (Mn3O4) can restore redox balance in a mouse model of UC induced by dextran sulfate sodium (DSS). Our in-vitro characterization of the developed nanoparticle confirms critical electronic transitions in the nanoparticle to be important for the redox buffering activity in the animal model. A careful administration of the developed nanoparticle not only reduces inflammatory markers in the animals, but also reduces the mortality rate from the induced disease. This study provides a proof of concept for the use of nanomaterial with synergistic anti-inflammatory and redox buffering capacity to prevent and treat ulcerative colitis.

Original languageEnglish
Article number647
JournalCommunications Biology
Volume6
Issue number1
DOIs
Publication statusPublished - Dec 2023

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • General Biochemistry,Genetics and Molecular Biology
  • General Agricultural and Biological Sciences

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