Clinical "case series": A concept analysis

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87 Citations (Scopus)


Objectives: To analyze the concept of "case series" in the medical literature compared with case reports. Methods: A PubMed search for articles published during 2009 which had "case series" in their title was performed. A total number of 621 articles were retrieved. 586 papers were included in the analysis and 35 were excluded (18 were commentary letters, 5 were not in English, and twelve could not be retrieved by our Library). The number of patients and category of these articles were analyzed. Results: The median (range) of the number of cases of articles having "case series" in their title was 7 (1-6432) cases. 186/ 586 articles had less than 5 cases (31.7%, 95% CI (28.3-35.1%)). The median (range) of the number of cases of articles having "case report" as their publication type was 4 (1-178) cases. Out of the 219 articles categorized as case reports 114 (52.1%, 95% CI (45.6-58.6%)) had less than five cases. Conclusions: The concept of "case series" is not well defined in the literature and does not reflect a specific research design. We suggest that a case series should have more than four patients while four paitents or less should be reported individually as case reports.

Original languageEnglish
Pages (from-to)557-562
Number of pages6
JournalAfrican Health Sciences
Issue number4
Publication statusPublished - 2012


  • Case report
  • Case series
  • Concept analysis
  • Research design

ASJC Scopus subject areas

  • General Medicine


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