Clinical features at first visit and rapid disease progression in Parkinson's disease

Leslie W. Ferguson, Michele L. Rajput, Nazeem Muhajarine, Syed M. Shah, Alexander Rajput

Research output: Contribution to journalArticlepeer-review

22 Citations (Scopus)


We report a retrospective multivariable analysis of the association between patient characteristics at first clinic visit and rapid disease progression in 1411 Parkinson's disease patients treated between 1985 and 2006. At first visit rapid progression was positively associated with age at onset ≥ 70 years (OR = 5.77), rigidity (OR = 1.94), bradykinesia (OR = 1.73), dementia (OR = 2.61), and levodopa use (OR = 1.74). Rapid progression was negatively associated with disease duration (OR = 0.52), male sex (OR = 0.49), and resting tremor at first visit (OR = 0.44). Family history of movement disorders, while significant for univariable analysis, did not retain significance in multivariable analysis. This initial clinical profile may aid physicians in adjusting treatment and follow-up plans. Further prospective studies are needed to evaluate this relationship.

Original languageEnglish
Pages (from-to)431-435
Number of pages5
JournalParkinsonism and Related Disorders
Issue number5
Publication statusPublished - Jul 2008
Externally publishedYes


  • Disease progression
  • Parkinson disease
  • Prognostic factors
  • Rapid progression

ASJC Scopus subject areas

  • Neurology
  • Geriatrics and Gerontology
  • Clinical Neurology


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