Codeine phosphate abolishes the pancreatic polypeptide response to oral fat

T. E. Adrian, N. D. Christofides, L. O. Uttenthal

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)


Plasma concentrations of pancreatic polypeptide (PP) were measured after the ingestion of 140 g of double cream in 5 healthy subjects on 2 occasions. On one day fat ingestion followed 1 h after 30 mg codeine phosphate (i.v.) and on the other day no drug was given. On the control day PP levels rose after cream from 28±3 pmol/l (mean±SEM) to a peak of 229±73 at 60 min. This postprandial response was completely abolished by codeine phosphate (basal 30±9,60 min peak 34±6). Thus codeine phosphate, a drug commonly prescribed for cough, pain and diarrhoea, has a profound effect on the postprandial release of this hormonal peptide.

Original languageEnglish
Pages (from-to)223-225
Number of pages3
JournalBiomedical Research
Issue number2
Publication statusPublished - 1982
Externally publishedYes

ASJC Scopus subject areas

  • General Biochemistry,Genetics and Molecular Biology


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