Cognitive function and depression in symptom resolution in schizophrenia patients treated with an atypical antipsychotic

Emmanuel Stip, Adham Mancini-Marïe

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)


Objective. To investigate which cognitive and affective features contribute most to responder/non-responder group separation during a switching trial with atypical antipsychotic. Design. A prospective open trial with an atypical antipsychotic (olanzapine). Patients. One hundred and thirty-four patients meeting diagnostic criteria for schizophrenia, schizophreniform or schizoaffective disorder began an 8-week open-label olanzapine treatment at a dose of 5mg/day which was increased to 10mg/day after one week. Interventions. Olanzapine during 8 weeks. Patients were considered as responders if their BPRS score decreased of at least 20% (n=96) and non-responders if it did not (n=38). Neuropsychological assessments were carried out at baseline, at four and at eight weeks. Results. Neurocognitive measures were analyzed for discriminate factors between responder and non-responder groups. A regression analysis was applied to explain the effects of depression on each cognitive variable. Depression was found to be a weak discriminant factor, however this finding could not firmly establish that depression is a potential factor in explaining deficits and improvements in cognition.

Original languageEnglish
Pages (from-to)463-465
Number of pages3
JournalBrain and Cognition
Issue number3
Publication statusPublished - Aug 2004
Externally publishedYes


  • Cognition
  • Depression
  • Memory
  • Olanzapine
  • Schizophrenia
  • Verbal fluency

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Experimental and Cognitive Psychology
  • Developmental and Educational Psychology
  • Arts and Humanities (miscellaneous)
  • Cognitive Neuroscience


Dive into the research topics of 'Cognitive function and depression in symptom resolution in schizophrenia patients treated with an atypical antipsychotic'. Together they form a unique fingerprint.

Cite this