TY - JOUR
T1 - Cold Oxidative Demetalation of Aryl Organometallics
T2 - A Novel Route to Demetalate Ullmann Intermediates without Heating
AU - Pérez Paz, Alejandro
N1 - Funding Information:
The author thanks the UAEU for an internal start-up grant (No. 31S410) and Prof. Abner de Siervo (UNICAMP, Brazil) for fruitful discussions about possible STM experiments. The author also thanks an anonymous referee for suggesting the ACID analysis.
Publisher Copyright:
© 2023 Wiley-VCH GmbH.
PY - 2023/3/13
Y1 - 2023/3/13
N2 - A new way of demetalating Ullmann organometallic aryl intermediates is proposed that uses charging rather than heating conditions. Ab initio molecular dynamics simulations show that certain aryl organosilver and organocopper intermediates (MPh2, with M=Cu, Ag and Ph=phenyl group) spontaneously demetalate even starting with zero velocities upon the oxidative removal of one electron. The oxidative demetalation is driven by the loss of electron density in the interatomic C−M region and leads to a biphenyl molecule with a η-coordinated nearby M atom. The main advantage of this dry redox demetalation process is that it avoids the use of high temperatures which have deleterious effects on the yields. The method does not compromise the thermal stability of the end product and reduces the chances of uncontrolled side reactions. The demetalation of oxidized MPh2 is predicted to occur spontaneously in the gas phase and on an inert surface. A possible experimental setup is proposed to test this idea in the widely-used Ullmann reaction for the controlled on-surface synthesis of new C−C bonds. The reduction-induced planarization of the neutral MPh2 molecule is reversible and could be used as an electro-mechanical nano-switch. The neutral and anionic compounds are predicted to be locally aromatic and dynamically stable. For bimetallic aryl intermediates (M2Ph3), the irreversible demetalation occurs upon the removal of two electrons leading to the dication.
AB - A new way of demetalating Ullmann organometallic aryl intermediates is proposed that uses charging rather than heating conditions. Ab initio molecular dynamics simulations show that certain aryl organosilver and organocopper intermediates (MPh2, with M=Cu, Ag and Ph=phenyl group) spontaneously demetalate even starting with zero velocities upon the oxidative removal of one electron. The oxidative demetalation is driven by the loss of electron density in the interatomic C−M region and leads to a biphenyl molecule with a η-coordinated nearby M atom. The main advantage of this dry redox demetalation process is that it avoids the use of high temperatures which have deleterious effects on the yields. The method does not compromise the thermal stability of the end product and reduces the chances of uncontrolled side reactions. The demetalation of oxidized MPh2 is predicted to occur spontaneously in the gas phase and on an inert surface. A possible experimental setup is proposed to test this idea in the widely-used Ullmann reaction for the controlled on-surface synthesis of new C−C bonds. The reduction-induced planarization of the neutral MPh2 molecule is reversible and could be used as an electro-mechanical nano-switch. The neutral and anionic compounds are predicted to be locally aromatic and dynamically stable. For bimetallic aryl intermediates (M2Ph3), the irreversible demetalation occurs upon the removal of two electrons leading to the dication.
KW - DFT
KW - On-surface demetalation
KW - organometallic aromaticity
KW - oxidative demetalation
KW - Ullmann reaction
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U2 - 10.1002/slct.202203973
DO - 10.1002/slct.202203973
M3 - Article
AN - SCOPUS:85150178612
SN - 2365-6549
VL - 8
JO - ChemistrySelect
JF - ChemistrySelect
IS - 10
M1 - e202203973
ER -